YRC Public Data Repository - Protein Structure Prediction

Protein:	TAF6
Organism:	Saccharomyces cerevisiae
Length:	516 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF6.

Description	E-value	Query Range	Subject Range
TAF6 - Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase... TAF6_YEAST - Transcription initiation factor TFIID subunit 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...	0.0	[1..516]	[1..516]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[15..473]	[10..427]
gi\|220943388 - gi\|220943388\|gb\|ACL84237.1\| Taf6-PA [synthetic construct] Taf6-PA - The gene TBP-associated factor 6 is referred to in FlyBase by the symbol Dmel\Taf6 (CG32211, FBgn001...	0.0	[15..473]	[24..441]
TAF6_MOUSE - Transcription initiation factor TFIID subunit 6 OS=Mus musculus GN=Taf6 PE=1 SV=1	0.0	[1..470]	[1..443]
gi\|1109650 - gi\|1109650\|dbj\|BAA08435.1\| TFIID subunit p80 [Rattus sp.] TAF6_RAT - Transcription initiation factor TFIID subunit 6 OS=Rattus norvegicus GN=Taf6 PE=1 SV=1	0.0	[1..470]	[1..443]
TAF6 - TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa gi\|123996257, gi... - gi\|123996257\|gb\|ABM85730.1\| TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor...	0.0	[1..470]	[1..443]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..470]	[1..443]
TAF6_XENLA - Transcription initiation factor TFIID subunit 6 OS=Xenopus laevis GN=taf6 PE=2 SV=2	0.0	[1..470]	[1..436]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQQQSYTI WSPQDTVKDV AESLGLENIN DDVLKALAMD VEYRILEIIE QAVKFKRHSK  60
   61 RDVLTTDDVS KALRVLNVEP LYGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.221849
Match:	1tafB_
Description:	TAF(II)62
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	9.25279783093877	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.97252613675094	bayes_pls_golite062009
histone acetyltransferase activity	5.97252613675094	bayes_pls_golite062009
N-acetyltransferase activity	4.49886535711761	bayes_pls_golite062009
DNA binding	4.49118409263799	bayes_pls_golite062009
nucleic acid binding	4.35201412176948	bayes_pls_golite062009
N-acyltransferase activity	4.22222466548509	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
transcription initiation factor activity	3.96621818094279	bayes_pls_golite062009
acetyltransferase activity	3.91614625961398	bayes_pls_golite062009
acyltransferase activity	3.38611688546892	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.35015681315177	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.28941584139552	bayes_pls_golite062009
binding	3.27510691458843	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.1782337747057	bayes_pls_golite062009
transcription factor activity	2.51581622888695	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
nucleotidyltransferase activity	1.10331930589736	bayes_pls_golite062009
protein binding	1.07873333188144	bayes_pls_golite062009
centromeric DNA binding	1.03586371237592	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
transcription repressor activity	0.72554769377984	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.437760073242714	bayes_pls_golite062009
histone binding	0.218942897869955	bayes_pls_golite062009
transferase activity	0.106182831892296	bayes_pls_golite062009
sequence-specific DNA binding	0.0852726470007639	bayes_pls_golite062009
transcription corepressor activity	0.0736756545988504	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [85-194]

      1          11         21         31         41         51         
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    1 YDGSEVNKAV SFSKVNTSGG QSVYYLDEEE VDFDRLINEP LPQVPRLPTF TTHWLAVEGV  60
   61 QPAIIQNPNL NDIRVSQPPF IRGAIVTALN DNSLQTPVTS TTASASVTDT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [195-306]

      1          11         21         31         41         51         
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    1 GASQHLSNVK PGQNTEVKPL VKHVLSKELQ IYFNKVISTL TAKSQADEAA QHMKQAALTS  60
   61 LRTDSGLHQL VPYFIQFIAE QITQNLSDLQ LLTTILEMIY SLLSNTSIFL DP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [475-516]

      1          11         21         31         41         51         
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    1 KGEKVTDEDK EKLLERCGVT IGFHILKRDD AKELISAIFF GE

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.22
Match:	1wq1G
Description:	p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [307-474]

      1          11         21         31         41         51         
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    1 YIHSLMPSIL TLLLAKKLGG SPKDDSPQEI HEFLERTNAL RDFAASLLDY VLKKFPQAYK  60
   61 SLKPRVTRTL LKTFLDINRV FGTYYGCLKG VSVLEGESIR FFLGNLNNWA RLVFNESGIT 120
  121 LDNIEEHLND DSNPTRTKFT KEETQILVDT VISALLVLKK DLPDLYEG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.22
Match:	1wq1G
Description:	p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [424-516]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GITLDNIEEH LNDDSNPTRT KFTKEETQIL VDTVISALLV LKKDLPDLYE GKGEKVTDED  60
   61 KEKLLERCGV TIGFHILKRD DAKELISAIF FGE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.841	a.112.1	Description not found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: