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Protein Overview: ATG8

General Information:
Name(s) found: ATG8 / YBL078C [SGD]
Description(s) found:
Found 36 descriptions.
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  • Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 117 amino acids

    Gene Ontology:
    Cellular Component: pre-autophagosomal structure [IDALink to PubMed articleLink to PubMed article]
    autophagic vacuole [IDALink to PubMed articleLink to PubMed article]
    microtubule associated complex [IPILink to PubMed article][ISSLink to PubMed article]
    Biological Process: autophagy [IGILink to PubMed article][IMPLink to PubMed article]
    C-terminal protein lipidation [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: microtubule binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSTFKSEYP FEKRKAESER IADRFKNRIP VICEKAEKSD IPEIDKRKYL VPADLTVGQF  60
   61 VYVIRKRIML PPEKAIFIFV NDTLPPTAAL MSAIYQEHKD KDGFLYVTYS GENTFGR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
    View Details Krogan NJ, et al. (2006) ATG8 ATP14
    View Details Qiu et al. (2008) ATG1 ATG16 ATG2 ATG20 ATG4 ATG5 ATG8 BIK1 SNX4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] PSI-BLAST 366.69897 Golgi-associated ATPase enhancer of 16 kD, Gate-16

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tubulin binding
    		•  3.8719684227967 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.71144418714309 bayes_pls_golite062009
  • microtubule binding
    		•  3.61517229466799 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.30801071565148 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.11253399564789 bayes_pls_golite062009
  • beta-tubulin binding
    		•  2.878827078106 bayes_pls_golite062009
  • binding
    		•  2.786655943372 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.72499875710239 bayes_pls_golite062009
  • GABA receptor binding
    		•  2.41579236188889 bayes_pls_golite062009
  • protein tag
    		•  2.15059229834935 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.42747465816672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32707653701567 bayes_pls_golite062009
  • DNA binding
    		•  1.22622447288034 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.87452559909702 bayes_pls_golite062009
  • signal transducer activity
    		•  0.87452559909702 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.80391127659342 bayes_pls_golite062009
  • hydrolase activity
    		•  0.79940718386175 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.753885975469065 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.599634454232833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.576819726104993 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • transferase activity
    		•  0.236208643697075 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle