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Protein Overview: ATG4

General Information:
Name(s) found: ATG4 / YNL223W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: microtubule associated complex [IPILink to PubMed article]
    Biological Process: autophagy [IGILink to PubMed article][IMPLink to PubMed article]
    C-terminal protein lipidation [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]
    microtubule binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRWLQLWKM DLVQKVSHGV FEGSSEEPAA LMNHDYIVLG EVYPERDEES GAEQCEQDCR  60
   61 YRGEAVSDGF LSSLFGREIS SYTKEFLLDV QSRVNFTYRT RFVPIARAPD GPSPLSLNLL 120
  121 VRTNPISTIE DYIANPDCFN TDIGWGCMIR TGQSLLGNAL QILHLGRDFR VNGNESLERE 180
  181 SKFVNWFNDT PEAPFSLHNF VSAGTELSDK RPGEWFGPAA TARSIQSLIY GFPECGIDDC 240
  241 IVSVSSGDIY ENEVEKVFAE NPNSRILFLL GVKLGINAVN ESYRESICGI LSSTQSVGIA 300
  301 GGRPSSSLYF FGYQGNEFLH FDPHIPQPAV EDSFVESCHT SKFGKLQLSE MDPSMLIGIL 360
  361 IKGEKDWQQW KLEVAESAII NVLAKRMDDF DVSCSMDDVE SVSSNSMKKD ASNNENLGVL 420
  421 EGDYVDIGAI FPHTTNTEDV DEYDCFQDIH CKKQKIVVMG NTHTVNANLT DYEVEGVLVE 480
  481 KETVGIHSPI DEKC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
    View Details Ho Y, et al. (2002) ATG4 CDC15 TFP1
    View Details Qiu et al. (2008) ASE1 ATG4 ATG8 NIP100 STU2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ATG4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] deduced N/A No confident structure predictions are available.
    2 View Details [144..298] MSA 1.035968 View MSA. No confident structure predictions are available.
    3 View Details [299..393] MSA 2.035971 View MSA. No confident structure predictions are available.
    4 View Details [394..494] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  2.8192612691912 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.71117522993364 bayes_pls_golite062009
  • hydrolase activity
    		•  2.66167923792227 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.56654871607946 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.55227247835105 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.13397229861051 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • tubulin binding
    		•  1.85112496470487 bayes_pls_golite062009
  • microtubule binding
    		•  1.82320858139311 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.48823471197032 bayes_pls_golite062009
  • binding
    		•  1.34325419334831 bayes_pls_golite062009
  • protein binding
    		•  1.08139200376412 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.954652694395915 bayes_pls_golite062009
  • transporter activity
    		•  0.69523261160023 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.439003000540428 bayes_pls_golite062009
  • structural molecule activity
    		•  0.297752217869698 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.289910308044519 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.125654358663332 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0241561776323942 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle