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Catalysis of the hydrolysis of peptide bonds formed between L-amino acids. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: cysteine-type endopeptidase activity
Acc: GO:0004197
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms:
  • lysosomal cysteine-type endopeptidase
  • thiol endopeptidase activity
Proteins in PDR annotated with:
   This term: 311 [Search]
   Term or descendants: 357 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004197 - cysteine-type endopeptidase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle