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Protein Overview: HAP1

General Information:
Name(s) found: HAP1 / YLR256W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1502 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: aerobic respiration [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTPYNSSV PSIASMTQSS VSRSPNMHTA TTPGANTSSN SPPLHMSSDS SKIKRKRNRI  60
   61 PLSCTICRKR KVKCDKLRPH CQQCTKTGVA HLCHYMEQTW AEEAEKELLK DNELKKLRER 120
  121 VKSLEKTLSK VHSSPSSNSL KSYNTPESSN LFMGSDEHTT LVNANTGSAS SASHMHQQQQ 180
  181 QQQQQEQQQD FSRSANANAN SSSLSISNKY DNDELDLTKD FDLLHIKSNG TIHLGATHWL 240
  241 SIMKGDPYLK LLWGHIFAMR EKLNEWYYQK NSYSKLKSSK CPINHAQAPP SAAAAATRKC 300
  301 PVDHSAFSSG MVAPKEETPL PRKCPVDHTM FSSGMIPPRE DTSSQKRCPV DHTMYSAGMM 360
  361 PPKDETPSPF STKAMIDHNK HTMNPPQSKC PVDHRNYMKD YPSDMANSSS NPASRCPIDH 420
  421 SSMKNTAALP ASTHNTIPHH QPQSGSHARS HPAQSRKHDS YMTESEVLAT LCEMLPPKRV 480
  481 IALFIEKFFK HLYPAIPILD EQNFKNHVNQ MLSLSSMNPT VNNFGMSMPS SSTLENQPIT 540
  541 QINLPKLSDS CNLGILIIIL RLTWLSIPSN SCEVDLGEES GSFLVPNESS NMSASALTSM 600
  601 AKEESLLLKH ETPVEALELC QKYLIKFDEL SSISNNNVNL TTVQFAIFYN FYMKSASNDL 660
  661 TTLTNTNNTG MANPGHDSES HQILLSNITQ MAFSCGLHRD PDNFPQLNAT IPATSQDVSN 720
  721 NGSKKANPST NPTLNNNMSA ATTNSSSRSG SADSRSGSNP VNKKENQVSI ERFKHTWRKI 780
  781 WYYIVSMDVN QSLSLGSPRL LRNLRDFSDT KLPSASRIDY VRDIKELIIV KNFTLFFQID 840
  841 LCIIAVLNHI LNVSLARSVR KFELDSLINL LKNLTYGTEN VNDVVSSLIN KGLLPTSEGG 900
  901 SVDSNNDEIY GLPKLPDILN HGQHNQNLYA DGRNTSSSDI DKKLDLPHES TTRALFFSKH 960
  961 MTIRMLLYLL NYILFTHYEP MGSEDPGTNI LAKEYAQEAL NFAMDGYRNC MIFFNNIRNT1020
 1021 NSLFDYMNVI LSYPCLDIGH RSLQFIVCLI LRAKCGPLTG MRESSIITNG TSSGFNSSVE1080
 1081 DEDVKVKQES SDELKKDDFM KDVNLDSGDS LAEILMSRML LFQKLTKQLS KKYNYAIRMN1140
 1141 KSTGFFVSLL DTPSKKSDSK SGGSSFMLGN WKHPKVSNMS GFLAGDKDQL QKCPVYQDAL1200
 1201 GFVSPTGANE GSAPMQGMSL QGSTARMGGT QLPPIRSYKP ITYTSSNLRR MNETGEAEAK1260
 1261 RRRFNDGYID NNSNNDIPRG ISPKPSNGLS SVQPLLSSFS MNQLNGGTIP TVPSLTNITS1320
 1321 QMGALPSLDR ITTNQINLPD PSRDEAFDNS IKQMTPMTSA FMNANTTIPS STLNGNMNMN1380
 1381 GAGTANTDTS ANGSALSTLT SPQGSDLASN SATQYKPDLE DFLMQNSNFN GLMINPSSLV1440
 1441 EVVGGYNDPN NLGRNDAVDF LPVDNVEIDG VGIKINYHLL TSIYVTSILS YTVLEDDAND1500
 1501 EK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BIM1 BMH1 GTS1 HAP1 RCN2 SFL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] PSI-BLAST 463.770868 Hap1 (Cyp1); HAP1
    2 View Details [169..1502] deduced N/A No confident structure predictions are available.
    3 View Details [202..283] deduced N/A No confident structure predictions are available.
    4 View Details [284..462] deduced N/A No confident structure predictions are available.
    5 View Details [463..710] deduced N/A No confident structure predictions are available.
    6 View Details [711..756] deduced N/A No confident structure predictions are available.
    7 View Details [757..891] deduced N/A No confident structure predictions are available.
    8 View Details [892..1073] deduced N/A No confident structure predictions are available.
    9 View Details [1074..1266] deduced N/A No confident structure predictions are available.
    10 View Details [1267..1387] deduced N/A No confident structure predictions are available.
    11 View Details [1388..1456] deduced N/A No confident structure predictions are available.
    12 View Details [1457..1502] MSA 1.002991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle