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Protein Overview: DAD3

General Information:
Name(s) found: DAD3 / YBR233W-A [SGD]
Description(s) found:
Found 22 descriptions.
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  • Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 94 amino acids

    Gene Ontology:
    Cellular Component: DASH complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    spindle [IDALink to PubMed article]
    kinetochore [IDALink to PubMed article]
    Biological Process: mitotic spindle organization in nucleus [IPILink to PubMed articleLink to PubMed article]
    mitosis [IMPLink to PubMed article]
    regulation of microtubule polymerization or depolymerization [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHNLSPLQQ EVLDKYKQLS LDLKALDETI KELNYSQHRQ QHSQQETVSP DEILQEMRDI  60
   61 EVKIGLVGTL LKGSVYSLIL QRKQEQESLG SNSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DAD3 DUO1 SPC19
    View Details (MIPS) Mewes HW, et al. (2004) ASK1 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 SPC19 SPC34
    View Details Krogan NJ, et al. (2006) DAD2 DAD3 YMR075C-A
    View Details Qiu et al. (2008) ARP10 ASE1 ASK1 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 FPR4 HSK3 IPL1 MND1 PCC1 REC102 SPC19 SPC34 SPO13 TWF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 No Comments Cheeseman IM, et al. (2002)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DAD3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] Pfam 47.29243 No description for PF08656.1 was found. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle