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Protein Overview: KIP1

General Information:
Name(s) found: KIP1 / YBL063W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1111 amino acids

    Gene Ontology:
    Cellular Component: spindle microtubule [TASLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    kinesin complex [TASLink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    mitotic anaphase B [IMPLink to PubMed article]
    Molecular Function: microtubule motor activity [TASLink to PubMed article]
    structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSSLPNRR TAQFEANKRR TIAHAPSPSL SNGMHTLTPP TCNNGAATSD SNIHVYVRCR  60
   61 SRNKREIEEK SSVVISTLGP QGKEIILSNG SHQSYSSSKK TYQFDQVFGA ESDQETVFNA 120
  121 TAKNYIKEML HGYNCTIFAY GQTGTGKTYT MSGDINILGD VQSTDNLLLG EHAGIIPRVL 180
  181 VDLFKELSSL NKEYSVKISF LELYNENLKD LLSDSEDDDP AVNDPKRQIR IFDNNNNNSS 240
  241 IMVKGMQEIF INSAHEGLNL LMQGSLKRKV AATKCNDLSS RSHTVFTITT NIVEQDSKDH 300
  301 GQNKNFVKIG KLNLVDLAGS ENINRSGAEN KRAQEAGLIN KSLLTLGRVI NALVDHSNHI 360
  361 PYRESKLTRL LQDSLGGMTK TCIIATISPA KISMEETAST LEYATRAKSI KNTPQVNQSL 420
  421 SKDTCLKDYI QEIEKLRNDL KNSRNKQGIF ITQDQLDLYE SNSILIDEQN LKIHNLREQI 480
  481 KKFKENYLNQ LDINNLLQSE KEKLIAIIQN FNVDFSNFYS EIQKIHHTNL ELMNEVIQQR 540
  541 DFSLENSQKQ YNTNQNMQLK ISQQVLQTLN TLQGSLNNYN SKCSEVIKGV TEELTRNVNT 600
  601 HKAKHDSTLK SLLNITTNLL MNQMNELVRS ISTSLEIFQS DSTSHYRKDL NEIYQSHQQF 660
  661 LKNLQNDIKS CLDSIGSSIL TSINEISQNC TTNLNSMNVL IENQQSGSSK LIKEQDLEIK 720
  721 KLKNDLINER RISNQFNQQL AEMKRYFQDH VSRTRSEFHD ELNKCIDNLK DKQSKLDQDI 780
  781 WQKTASIFNE TDIVVNKIHS DSIASLAHNA ENTLKTVSQN NESFTNDLIS LSRGMNMDIS 840
  841 SKLRSLPINE FLNKISQTIC ETCGDDNTIA SNPVLTSIKK FQNIICSDIA LTNEKIMSLI 900
  901 DEIQSQIETI SNENNINLIA INENFNSLCN FILTDYDENI MQISKTQDEV LSEHCEKLQS 960
  961 LKILGMDIFT AHSIEKPLHE HTRPEASVIK ALPLLDYPKQ FQIYRDAENK SKDDTSNSRT1020
 1021 CIPNLSTNEN FPLSQFSPKT PVPVPDQPLP KVLIPKSINS AKSNRSKTLP NTEGTGRESQ1080
 1081 NNLKRRFTTE PILKGEETEN NDILQNKKLH Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CIK1 CIN8 COG7 KAR3 KIP1 KIP2 KIP3 LIN1
    View Details Krogan NJ, et al. (2006) KIP1 PRP22 SOK2
    View Details Qiu et al. (2008) ARP1 ARP10 BIK1 CIK1 CIN8 DYN3 KAR3 KIP1 KIP2 KIP3 NUF2 STU1 STU2 TUB1 VIK1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KIP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..419] PSI-BLAST 971.9897 Kinesin
    2 View Details [420..488] deduced N/A No confident structure predictions are available.
    3 View Details [489..787] ORFEUS 7.73 Botulinum neurotoxin
    4 View Details [788..1111] PSI-BLAST 13.69897 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.724847255896311 bayes_pls_golite062009
  • translation regulator activity
    		•  0.68989258674288 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle