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Protein Overview: SOK2

General Information:
Name(s) found: SOK2 / YMR016C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 785 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: transcription factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS VQPLMPVSYQ  60
   61 YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS GSDSNASNPP STSVGVPSNA 120
  121 TATALPNGSA ITTKKSNNST NISNNVPYYY YFPQMQAQQS MAYSYPQAYY YYPANGDGTT 180
  181 NGATPSVTSN QVQNPNLEKT YSTFEQQQQH QQQQQLQAQT YPAQPPKIGN AFSKFSKSGP 240
  241 PSDSSSGSMS PNSNRTSRNS NSISSLAQQP PMSNYPQPST YQYPGFHKTS SIPNSHSPIP 300
  301 PRSLTTPTQG PTSQNGPLSY NLPQVGLLPP QQQQQVSPLY DGNSITPPVK PSTDQETYLT 360
  361 ANRHGVSDQQ YDSMAKTMNS FQTTTIRHPM PLIATTNATG SNTSGTSASI IRPRVTTTMW 420
  421 EDEKTLCYQV EANGISVVRR ADNDMVNGTK LLNVTKMTRG RRDGILKAEK IRHVVKIGSM 480
  481 HLKGVWIPFE RALAIAQREK IADYLYPLFI RDIQSVLKQN NPSNDSSSSS SSTGIKSISP 540
  541 RTYYQPINNY QNPNGPSNIS AAQLTYSSMN LNNKIIPNNS IPAVSTIAAG EKPLKKCTMP 600
  601 NSNQLEGHTI TNLQTLSATM PMKQQLMGNI ASPLSYPRNA TMNSASTLGI TPADSKPLTP 660
  661 SPTTTNTNQS SESNVGSIHT GITLPRVESE SASHSKWSKE ADSGNTVPDN QTLKEPRSSQ 720
  721 LPISALTSTD TDKIKTSTSD EATQPNEPSE AEPVKESESS KSQVDGAGDV SNEEIAADDT 780
  781 KKQEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) KIP1 PRP22 SOK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SOK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] ORFEUS 11.3 Fibrinogen
    2 View Details [126..414] ORFEUS 10.23 Fibrinogen
    3 View Details [415..509] PSI-BLAST 55.457575 DNA-binding domain of Mlu1-box binding protein MBP1
    4 View Details [510..785] ORFEUS 14.24 No description for 1ldvA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.26527143246279 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.07644812724504 bayes_pls_golite062009
  • DNA binding
    		•  3.05936134509304 bayes_pls_golite062009
  • transcription factor activity
    		•  3.03273011916245 bayes_pls_golite062009
  • binding
    		•  2.59301091515687 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.56159546283906 bayes_pls_golite062009
  • protein binding
    		•  0.404450175883241 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.26364919885147 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle