YRC Public Data Repository - Protein Structure Prediction

Protein:	SOK2
Organism:	Saccharomyces cerevisiae
Length:	785 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOK2.

Description	E-value	Query Range	Subject Range
SOK2 - Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA)... SOK2_YEAST - Protein SOK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SOK2 PE=1 SV=1 gi\|190408256 - gi\|190408256\|gb\|EDV11521.1\| protein SOK2 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..785]	[1..785]
SYNJ1_RAT, SYJ1_RAT - (Q62910) Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1), (Q629...	2.0E-45	[9..431]	[991..1439]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-44	[9..431]	[991..1440]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	4.0E-44	[9..431]	[991..1423]
gi\|5139660 - gi\|5139660\|emb\|CAB45654.1\| mycelial growth factor-1 [Yarrowia lipolytica]	4.0E-42	[265..535]	[3..240]
gi\|28949997, gi\|... - gi\|32412854\|ref\|XP_326907.1\| hypothetical protein ( (U51117) ascospore maturation 1 protein [Neurosp... STUA_NEUCR - Cell pattern formation-associated protein asm-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A...	4.0E-39	[293..534]	[3..234]
STUA_EMENI - Cell pattern formation-associated protein stuA OS=Emericella nidulans GN=stuA PE=2 SV=2 STUA_EMENI - Cell pattern formation-associated protein stuA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 /...	1.0E-38	[290..533]	[6..248]

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Predicted Domain #1

Region A:
Residues: [1-125]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIGNPINTN DIKSNRMRQE SNMSAVSNSE STIGQSTQQQ QQQQQYLGQS VQPLMPVSYQ  60
   61 YVVPEQWPYP QYYQQPQSQS QQQLQSQPQM YQVQESFQSS GSDSNASNPP STSVGVPSNA 120
  121 TATAL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.3
Match:	1deqA
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [126-414]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNGSAITTKK SNNSTNISNN VPYYYYFPQM QAQQSMAYSY PQAYYYYPAN GDGTTNGATP  60
   61 SVTSNQVQNP NLEKTYSTFE QQQQHQQQQQ LQAQTYPAQP PKIGNAFSKF SKSGPPSDSS 120
  121 SGSMSPNSNR TSRNSNSISS LAQQPPMSNY PQPSTYQYPG FHKTSSIPNS HSPIPPRSLT 180
  181 TPTQGPTSQN GPLSYNLPQV GLLPPQQQQQ VSPLYDGNSI TPPVKPSTDQ ETYLTANRHG 240
  241 VSDQQYDSMA KTMNSFQTTT IRHPMPLIAT TNATGSNTSG TSASIIRPR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.23
Match:	1ei3A
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [415-509]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTTTMWEDEK TLCYQVEANG ISVVRRADND MVNGTKLLNV TKMTRGRRDG ILKAEKIRHV  60
   61 VKIGSMHLKG VWIPFERALA IAQREKIADY LYPLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.457575
Match:	1bm8__
Description:	DNA-binding domain of Mlu1-box binding protein MBP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.26527143246279	bayes_pls_golite062009
nucleic acid binding	3.07644812724504	bayes_pls_golite062009
DNA binding	3.05936134509304	bayes_pls_golite062009
transcription factor activity	3.03273011916245	bayes_pls_golite062009
binding	2.59301091515687	bayes_pls_golite062009
sequence-specific DNA binding	1.56159546283906	bayes_pls_golite062009
protein binding	0.404450175883241	bayes_pls_golite062009
transcription repressor activity	0.26364919885147	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [510-785]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRDIQSVLKQ NNPSNDSSSS SSSTGIKSIS PRTYYQPINN YQNPNGPSNI SAAQLTYSSM  60
   61 NLNNKIIPNN SIPAVSTIAA GEKPLKKCTM PNSNQLEGHT ITNLQTLSAT MPMKQQLMGN 120
  121 IASPLSYPRN ATMNSASTLG ITPADSKPLT PSPTTTNTNQ SSESNVGSIH TGITLPRVES 180
  181 ESASHSKWSK EADSGNTVPD NQTLKEPRSS QLPISALTST DTDKIKTSTS DEATQPNEPS 240
  241 EAEPVKESES SKSQVDGAGD VSNEEIAADD TKKQEK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.24
Match:	1ldvA
Description:	No description for 1ldvA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: