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View Structure Prediction Details

Protein: KIP1
Organism: Saccharomyces cerevisiae
Length: 1111 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KIP1.

Description E-value Query
Range		 Subject
Range
KIP1_YEAST - Kinesin-like protein KIP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KIP1 PE=1 SV=1
KIP1 - Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 m...
 0.0 [1..1111] [1..1111]
gi|4512330 - gi|4512330|dbj|BAA75243.1| KIF1B-beta [Mus musculus]
 0.0 [49..829] [2..742]
KIF1B - kinesin family member 1B
 0.0 [49..829] [2..788]
gi|15208453 - gi|15208453|gb|AAK91815.1|AF272752_1 kinesin heavy chain [Zea mays]
 0.0 [25..973] [25..967]
gi|8248421 - gi|8248421|gb|AAF74192.1|AF247761_1 kinesin superfamily member DUnc104 [Drosophila melanogaster]
 0.0 [51..829] [2..748]
K125_ARATH - Probable 125 kDa kinesin-related protein OS=Arabidopsis thaliana GN=At2g36200 PE=2 SV=1
 0.0 [42..975] [2..945]
KN5C_TOBAC - Kinesin-like protein KIN-5C OS=Nicotiana tabacum GN=KIN5C PE=1 SV=1
 0.0 [47..974] [4..940]

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Predicted Domain #1
Region A:
Residues: [1-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSSLPNRR TAQFEANKRR TIAHAPSPSL SNGMHTLTPP TCNNGAATSD SNIHVYVRCR  60
   61 SRNKREIEEK SSVVISTLGP QGKEIILSNG SHQSYSSSKK TYQFDQVFGA ESDQETVFNA 120
  121 TAKNYIKEML HGYNCTIFAY GQTGTGKTYT MSGDINILGD VQSTDNLLLG EHAGIIPRVL 180
  181 VDLFKELSSL NKEYSVKISF LELYNENLKD LLSDSEDDDP AVNDPKRQIR IFDNNNNNSS 240
  241 IMVKGMQEIF INSAHEGLNL LMQGSLKRKV AATKCNDLSS RSHTVFTITT NIVEQDSKDH 300
  301 GQNKNFVKIG KLNLVDLAGS ENINRSGAEN KRAQEAGLIN KSLLTLGRVI NALVDHSNHI 360
  361 PYRESKLTRL LQDSLGGMTK TCIIATISPA KISMEETAST LEYATRAKSI KNTPQVNQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 971.9897
Match: 1ii6A_
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 7.68336791348661 bayes_pls_golite062009
plus-end-directed microtubule motor activity 4.97507344344589 bayes_pls_golite062009
microfilament motor activity 4.176620576177 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin-dependent ATPase activity 2.77140616759165 bayes_pls_golite062009
microtubule plus-end binding 2.71138928021716 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
transporter activity 2.58140740499725 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
transmembrane transporter activity 2.39695871109024 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
ATPase activity, coupled 2.18396165590908 bayes_pls_golite062009
ATP-dependent DNA helicase activity 2.07967285635739 bayes_pls_golite062009
actin binding 1.75397031486306 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.40384549325664 bayes_pls_golite062009
helicase activity 1.33212695797068 bayes_pls_golite062009
substrate-specific transporter activity 1.29730375126024 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.07479235523606 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.906554174337376 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
actin filament binding 0.728264616959762 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.724847255896311 bayes_pls_golite062009
translation regulator activity 0.68989258674288 bayes_pls_golite062009
structure-specific DNA binding 0.579644950922817 bayes_pls_golite062009
kinetochore binding 0.505370954958131 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
guanyl nucleotide binding 0.399434758448606 bayes_pls_golite062009
GTP binding 0.398333597279278 bayes_pls_golite062009
guanyl ribonucleotide binding 0.39332178627529 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
ion transmembrane transporter activity 0.355466224802969 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
histone acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
ATP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.25143870859482 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein transporter activity 0.178442534411253 bayes_pls_golite062009
DNA helicase activity 0.17029946873911 bayes_pls_golite062009
mismatched DNA binding 0.13866566261611 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
cation transmembrane transporter activity 0.0254369227200564 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [420-488] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSKDTCLKDY IQEIEKLRND LKNSRNKQGI FITQDQLDLY ESNSILIDEQ NLKIHNLREQ  60
   61 IKKFKENYL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [489-787] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQLDINNLLQ SEKEKLIAII QNFNVDFSNF YSEIQKIHHT NLELMNEVIQ QRDFSLENSQ  60
   61 KQYNTNQNMQ LKISQQVLQT LNTLQGSLNN YNSKCSEVIK GVTEELTRNV NTHKAKHDST 120
  121 LKSLLNITTN LLMNQMNELV RSISTSLEIF QSDSTSHYRK DLNEIYQSHQ QFLKNLQNDI 180
  181 KSCLDSIGSS ILTSINEISQ NCTTNLNSMN VLIENQQSGS SKLIKEQDLE IKKLKNDLIN 240
  241 ERRISNQFNQ QLAEMKRYFQ DHVSRTRSEF HDELNKCIDN LKDKQSKLDQ DIWQKTASI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.73
Match: 1epwA
Description: Botulinum neurotoxin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [788-1111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNETDIVVNK IHSDSIASLA HNAENTLKTV SQNNESFTND LISLSRGMNM DISSKLRSLP  60
   61 INEFLNKISQ TICETCGDDN TIASNPVLTS IKKFQNIICS DIALTNEKIM SLIDEIQSQI 120
  121 ETISNENNIN LIAINENFNS LCNFILTDYD ENIMQISKTQ DEVLSEHCEK LQSLKILGMD 180
  181 IFTAHSIEKP LHEHTRPEAS VIKALPLLDY PKQFQIYRDA ENKSKDDTSN SRTCIPNLST 240
  241 NENFPLSQFS PKTPVPVPDQ PLPKVLIPKS INSAKSNRSK TLPNTEGTGR ESQNNLKRRF 300
  301 TTEPILKGEE TENNDILQNK KLHQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle