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Protein Overview: SPC105

General Information:
Name(s) found: SPC105 / YGL093W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 917 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVDERSRIG GREKDAGPGK GILKQNQSSQ MTSSFLENPG VRIPTRIITK KEVLDGSNTT  60
   61 SRINTSNLQS MVKRRVSFAP DVTLHSFTFV PEQNNEIKEP RRRKTSTNSP TKISSQEEPL 120
  121 VTSTQIDDAR TEEKTAAEED PDTSGMELTE PIVATPDSNK ASQHDPTSME MTEVFPRSIR 180
  181 QKNPDVEGES IESSQQIDDV EAVREETMEL TAIHNVHDYD SISKDTVEGE PIDLTEYESK 240
  241 PYVPNSVSRS TGKSSDYSVE RSNDKSDLSK SENKTNSSQP MEITDIFHAD PQNPMSLHSD 300
  301 NNINNDGNEM ELTQIQTNFD RDNHHIDESP SEKHAFSSNK RRKLDTVSDY AASVTTPVKE 360
  361 AKDTSGEDND GDLEMMEKMS PITFSDVDNK IGTRSNDVFT IEPGTEDTGM QTATDDEEDG 420
  421 ENVDDNGNKI VEKTRLPEID KEGQSGIALP TQDYTLREFI NEVGVGFLDT KLIDDLDKKV 480
  481 NFPLNSFNFV ENQRIDNVFS AFYIDIPILE VEAFRCKELW RSINESKDKF KDFEAQIDKS 540
  541 HPPLLLQEYF SSDEKMKQLM RDQLQLVKGY SKLEAAMEWY EWRKKQLNGL ELILAENLNT 600
  601 LKREYEKLNE EVEKVNSIRG KIRKLNEAIK EEIRSLKNLP SDSYKPTLMN RIKIEAFKQE 660
  661 LMEHSISLSS SNDFTQEMRS LKLAIAKKSN DILTLRSEVA SIDKKIEKRK LFTRFDLPKL 720
  721 RDTLKILESL TGVRFLKFSK ATLSIAFLQL DDLRVDINLA NFKNNPLSSM KVMNDSNNDD 780
  781 MSYHLFTMLL KNVEAEHQDS MLSNLFFAMK KWRPLLKYIK LLKLLFPVKI TQTEEEEALL 840
  841 QFKDYDRRNK TAFFYVISLV SFAQGVFSEN GQIPMKVHIS TQQDYSPSRE VLSDRITHKI 900
  901 SGVLPSFTKS RIHLEFT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) BBP1 CDC31 CMD1 CNM67 KAR1 NUD1 SPC105 SPC110 SPC24 SPC25 SPC29 SPC42 SPC72
    View Details Krogan NJ, et al. (2006) SPC105 YDR532C
    View Details Qiu et al. (2008) ARP1 BBP1 CDC31 CNM67 MPS2 NDC1 NUD1 NUF2 SFI1 SPC105 SPC110 SPC19 SPC24 SPC29 SPC42 SPC72 SPC97 SPC98 STU1 STU2 TID3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPC105 Huh WK, et al. (2003)
    View Data SPC105 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] ORFEUS 10.56 RBP1
    2 View Details [372..483] ORFEUS 11.12 No description for 1ldvA was found.
    3 View Details [484..764] PSI-BLAST 5.045757 Heavy meromyosin subfragment
    4 View Details [765..917] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle