YRC Public Data Repository - Protein Structure Prediction

Protein:	SPC105
Organism:	Saccharomyces cerevisiae
Length:	917 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC105.

Description	E-value	Query Range	Subject Range
SP105_YEAST - Spindle pole body component SPC105 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPC10... gi\|151943715 - gi\|151943715\|gb\|EDN62025.1\| spindle pole component [Saccharomyces cerevisiae YJM789] SPC105 - Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochro...	0.0	[1..917]	[1..917]
spc7 - kinetochore protein Spc7 SPC7_SCHPO - Kinetochore protein spc7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=spc7 PE=1 SV=1	1.0E-76	[15..701]	[416..1128]
gi\|19171017, gi\|... - gi\|19173428\|ref\|NP_597231.1\| hypothetical protein ECU08_1010 [Encephalitozoon cuniculi GB-M1], gi\|19... gi\|19173428 - gi\|19173428\|ref\|NP_597231.1\| hypothetical protein ECU08_1010 [Encephalitozoon cuniculi GB-M1]	1.0E-69	[416..751]	[148..473]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-62	[33..707]	[888..1550]
gi\|16554449, gi\|... - gi\|16554449\|ref\|NP_003377.1\| zonadhesin isoform 3 [Homo sapiens], gi\|12667414\|gb\|AAK01433.1\|AF332977...	5.0E-56	[15..463]	[567..1029]

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Predicted Domain #1

Region A:
Residues: [1-371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVDERSRIG GREKDAGPGK GILKQNQSSQ MTSSFLENPG VRIPTRIITK KEVLDGSNTT  60
   61 SRINTSNLQS MVKRRVSFAP DVTLHSFTFV PEQNNEIKEP RRRKTSTNSP TKISSQEEPL 120
  121 VTSTQIDDAR TEEKTAAEED PDTSGMELTE PIVATPDSNK ASQHDPTSME MTEVFPRSIR 180
  181 QKNPDVEGES IESSQQIDDV EAVREETMEL TAIHNVHDYD SISKDTVEGE PIDLTEYESK 240
  241 PYVPNSVSRS TGKSSDYSVE RSNDKSDLSK SENKTNSSQP MEITDIFHAD PQNPMSLHSD 300
  301 NNINNDGNEM ELTQIQTNFD RDNHHIDESP SEKHAFSSNK RRKLDTVSDY AASVTTPVKE 360
  361 AKDTSGEDND G

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.56
Match:	1i3qA
Description:	RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [372-483]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLEMMEKMSP ITFSDVDNKI GTRSNDVFTI EPGTEDTGMQ TATDDEEDGE NVDDNGNKIV  60
   61 EKTRLPEIDK EGQSGIALPT QDYTLREFIN EVGVGFLDTK LIDDLDKKVN FP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.12
Match:	1ldvA
Description:	No description for 1ldvA was found.

Predicted Domain #3

Region A:
Residues: [484-764]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNSFNFVENQ RIDNVFSAFY IDIPILEVEA FRCKELWRSI NESKDKFKDF EAQIDKSHPP  60
   61 LLLQEYFSSD EKMKQLMRDQ LQLVKGYSKL EAAMEWYEWR KKQLNGLELI LAENLNTLKR 120
  121 EYEKLNEEVE KVNSIRGKIR KLNEAIKEEI RSLKNLPSDS YKPTLMNRIK IEAFKQELME 180
  181 HSISLSSSND FTQEMRSLKL AIAKKSNDIL TLRSEVASID KKIEKRKLFT RFDLPKLRDT 240
  241 LKILESLTGV RFLKFSKATL SIAFLQLDDL RVDINLANFK N

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.045757
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [765-917]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPLSSMKVMN DSNNDDMSYH LFTMLLKNVE AEHQDSMLSN LFFAMKKWRP LLKYIKLLKL  60
   61 LFPVKITQTE EEEALLQFKD YDRRNKTAFF YVISLVSFAQ GVFSENGQIP MKVHISTQQD 120
  121 YSPSREVLSD RITHKISGVL PSFTKSRIHL EFT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits