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Protein Overview: KAR5

General Information:
Name(s) found: KAR5 / YMR065W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: karyogamy involved in conjugation with cellular fusion [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEMRYVYLF AICIKFVSSS ELGKINNLLQ GRLIYTDNSV ATNVLESKFP FLKSTCVKDA  60
   61 LKLFLPQCIA NGLESIDAET RVETAIKLSI CEFQASGLGE IPENCMVDDL GSMMDCMFEL 120
  121 ESSSQWWTTY SGNYQRLSSI CYENLLPFEK EQILKLFLNI TELYDSFGDD VDTKLNHLMF 180
  181 QMEQDSQNFL DDLARMFRNY DNELRNATES NRIILENDLS FFRNKVNDVL YETSEQLEVQ 240
  241 IIEKNSQLMN EVDTVHHIMS DLADELAKND IKSKINDLKD DSLNNLQDLV EMSNDVKEYY 300
  301 SRNNKLVNTE LENFSMGLKK QLGGMSKDLS ESQMEAIELL QGFNSILHDS LLPSMTDEIV 360
  361 PEMTNFKNTL LQEWTAITST LNGDFALWNE EIFSTFNDIS EKLNGTKKKL DDIEIRVSLV 420
  421 HKNVMTMMRV LDFMWKTSKM IIRCGYLAVK NKYYWLLCSV VWIWSKYRTS RVNVKMIPIK 480
  481 RYYQWAALLL SIYLGAKTGS LIDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AME1 ARP1 BIK1 CIK1 DYN1 JNM1 KAR3 KAR5 NUF2 SPC19 SPC34 STU1 STU2 TID3
    View Details Qiu et al. (2008) KAR5 NUF2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] deduced N/A No confident structure predictions are available.
    2 View Details [109..205]
    [248..344]
    [408..504]    		 ORFEUS 7.42 Botulinum neurotoxin
    3 View Details [206..247]
    [345..407]    		 ORFEUS 7.42 Botulinum neurotoxin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle