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Protein Overview: PAC11

General Information:
Name(s) found: PAC11 / YDR488C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 533 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic dynein complex [TASLink to PubMed article]
    cytoplasmic microtubule [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: nuclear migration along microtubule [IMPLink to PubMed article]
    microtubule-based process [IGILink to PubMed article]
    Molecular Function: microtubule motor activity [ISSLink to PubMed article]
    plus-end-directed microtubule motor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERLKQLEEK RRQLKELRER RKQASLFPGS ETMGHHPTEV HAKATMVSVS VQTDMEEGSK  60
   61 IQEPQSAYLR RKEVITYDKG IQTDQIEEEQ LQENENHTTT DAVAIETTAA DENNKDKAEN 120
  121 DQPRLELAKP FLVEEAAATL SNASFARLET EVSASGQQAP SNMQQDKDNL MQWNMVSENL 180
  181 QSETDCDCIA QEYDPGKGVL VVVYLRLPPA DLQYASSEAA WSVVNVVKCD NASGRNGLLI 240
  241 DMVEFRGTRI MTATILRRYH PESNVISILL ATLTGKIILY ELRLKQKKPE TPVVYVVQRN 300
  301 MVARHYFQHP VVAVIETSSV QDQERVLVAA DNGNIMELSC LDLTVLRKPQ QLRPVPLSQL 360
  361 LSLENDTCTY TERLQRLAKF DEVGIACMAY TSEDPQYVWI GGEDGGIYKV FWDQPGPLYL 420
  421 SLDNNGFQPA ENHSTRVTGL EFHWDDARRL MLLLSCSTDW TVRLWDARAG KAIIGAPLLL 480
  481 GGPVLRARWL EKNNGGENSR TLRCQVWCAD GRLVVVNWAF DAKTSLYTAT VIS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) DYN1 DYN2 PAC11
    View Details Krogan NJ, et al. (2006) DYN2 PAC11
    View Details Ho Y, et al. (2002) BIO3 DYN2 PAC11 PRX1 YRM1
    View Details Qiu et al. (2008) ARP1 CIK1 DYN1 DYN2 DYN3 KAR3 KIP2 KIP3 MYO2 PAC11

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] MSA 2.139995 View MSA. Confident ab initio structure predictions are available.
    2 View Details [141..533] PSI-BLAST 37.69897 Tup1, C-terminal domain
    3 View Details [467..533] PSI-BLAST 32.69897 Cdc4 F-box and linker domains; Cdc4 propeller domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • binding
    		•  2.56763106794721 bayes_pls_golite062009
  • dynein binding
    		•  1.73730057055973 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.6857070194499 bayes_pls_golite062009
  • protein binding
    		•  1.11897341394404 bayes_pls_golite062009
  • dynactin binding
    		•  1.09205354470481 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.05679861435905 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.831480546979987 bayes_pls_golite062009
  • myosin binding
    		•  0.79466819364522 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.626057815566445 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.428715007921149 bayes_pls_golite062009
  • DNA binding
    		•  0.387799300258449 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.375646066797591 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.136160694936939 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • actin binding
    		•  0.120045107841246 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0588151480189092 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle