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Protein Overview: PRX1

General Information:
Name(s) found: PRX1 / YBL064C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 261 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR INSDAPNFDA  60
   61 DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK LKPEFDKRNV KLIGLSVEDV 120
  121 ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN VAFLYDMVDA EGFKNINDGS LKTVRSVFVI 180
  181 DPKKKIRLIF TYPSTVGRNT SEVLRVIDAL QLTDKEGVVT PINWQPADDV IIPPSVSNDE 240
  241 AKAKFGQFNE IKPYLRFTKS K

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) DOA4 PRX1
    View Details Ho Y, et al. (2002) BIO3 DYN2 PAC11 PRX1 YRM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..211] PSI-BLAST 534.221849 HorF6 peroxidase
    2 View Details [212..261] PSI-BLAST 534.221849 HorF6 peroxidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • selenium binding
    		•  2.92496040718744 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • alkyl hydroperoxide reductase activity
    		•  1.46071159007924 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptide binding
    		•  0.374493676068876 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle