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Protein Overview: YRM1

General Information:
Name(s) found: YRM1 / YOR172W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 786 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: drug transmembrane transport [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRGSLQDR ASPSEETVKK AQKRRKPIKS CAFCRKRKLR CDQQKPMCST CKTRGRSGCL  60
   61 YTEKFTHKIE TKELFGSTPN IELLKRIEDL EKRLDDKELT EKDVALSTSP FRNPYANFYY 120
  121 LQCKGSGRRI VYGPTSLRTH LSNDDNRFVN TYNQLWSKVK IERNRWKARH KWTMKPETQL 180
  181 LEGPPLEKTG SDILQQVCNV LPSFEQSSKI ITDFFNTELE TNEVSEVLDK TKIINDFTSS 240
  241 FLPSDELLPN GERRIEKLLP STKKNYYKIG VILMILCIRH FYKNTPEEIE KFLIMLTGLS 300
  301 TAKVYFIERA QFLLLKYYHR ELIWACGDDS HMISLVDLLC STAIMLGLHL NIREIYKNQE 360
  361 NIVGSMESLE NLWVWIILSD FNVSLNIGRC LAINSSYFQV DECENGERLP KNTNNYSSTV 420
  421 FFDQSNSCMG KLKRFLRLAR PMLDQIYDRS AFPDLAENCK KLRNFVETEF HPISYYTDSE 480
  481 LISKVPLCEI KVLAQVLNLL LTFYSLRYLI YKEKSVVLEN NILQTILVSF SLVINTTILC 540
  541 FNLDEKHFPE FFDHNCVHLP PFMALSLVYT NFLFPRASTG FCAFLYHKLT LFEKGYYLSS 600
  601 NIKDQEVTDW DLSTLNIPLD KAMNLLTAFK IHSDIFAKWS NDNNKQLRII MARSYTFVIN 660
  661 IALESIYRAV LEKVIKYRTE VENTWLQQLQ DELNGSYSLT DNVNTPIDPS LSDLGVTSAS 720
  721 PLAGNSPGLP PEEVRNNSEN ASHNNETGPI ETELAQTISN EFWTAYNLGW EELMSQPDYK 780
  781 YLFDTQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APP1 CST6 HMO1 MCM10 MIG1 SSA3 YRM1
    View Details Ho Y, et al. (2002) BIO3 PAC11 PRX1 YRM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YRM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] PSI-BLAST 70.228787 Hap1 (Cyp1); HAP1
    2 View Details [101..556] MSA 3.144972 View MSA. No confident structure predictions are available.
    3 View Details [557..786] MSA 1.034906 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle