Protein Overview: MIG1

General Information:
Name(s) found:	MIG1 / YGL035C [SGD]
Description(s) found: Found 30 descriptions. SHOW ALL	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase [SGD]
Organism:	Saccharomyces cerevisiae
Length:	504 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ] cytoplasm [IDA ] nuclear envelope lumen [IDA]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter by glucose [IDA][IGI][IMP]
Molecular Function:	sequence-specific DNA binding [IDA ] specific transcriptional repressor activity [IDA][IGI][IMP][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSPYPMTQV SNVDDGSLLK ESKSKSKVAA KSEAPRPHAC PICHRAFHRL EHQTRHMRIH  60
   61 TGEKPHACDF PGCVKRFSRS DELTRHRRIH TNSHPRGKRG RKKKVVGSPI NSASSSATSI 120
  121 PDLNTANFSP PLPQQHLSPL IPIAIAPKEN SSRSSTRKGR KTKFEIGESG GNDPYMVSSP 180
  181 KTMAKIPVSV KPPPSLALNN MNYQTSSAST ALSSLSNSHS GSRLKLNALS SLQMMTPIAS 240
  241 SAPRTVFIDG PEQKQLQQQQ NSLSPRYSNT VILPRPRSLT DFQGLNNANP NNNGSLRAQT 300
  301 QSSVQLKRPS SVLSLNDLLV GQRNTNESDS DFTTGGEDEE DGLKDPSNSS IDNLEQDYLQ 360
  361 EQSRKKSKTS TPTTMLSRST SGTNLHTLGY VMNQNHLHFS SSSPDFQKEL NNRLLNVQQQ 420
  421 QQEQHTLLQS QNTSNQSQNQ NQNQMMASSS SLSTTPLLLS PRVNMINTAI STQQTPISQS 480
  481 DSQVQELETL PPIRSLPLPF PHMD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		APP1 CST6 HMO1 MCM10 MIG1 SSA3 YRM1
View Details	Ho Y, et al. (2002)		MIG1 MSS116 NOP12

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MIG1	YPL025C	2	Uetz P, et al. (2000)
View Screen	ILM1	MIG1	2	Lockshon D, et al. (2006)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MIG1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89]	PSI-BLAST	134.70927	No description for 1lu6A_ was found.
2	View Details	[90..193]	PSI-BLAST	134.70927	No description for 1lu6A_ was found.
3	View Details	[194..254]	MSA	31.033996	View MSA. Confident ab initio structure predictions are available.
4	View Details	[255..433]	MSA	1.778997	View MSA. No confident structure predictions are available.
5	View Details	[434..504]	deduced	N/A	Confident ab initio structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	4.47951889934838	bayes_pls_golite062009
nucleic acid binding	4.35187767955595	bayes_pls_golite062009
DNA binding	4.31051339571017	bayes_pls_golite062009
transcription factor activity	3.28758716579796	bayes_pls_golite062009
transcription repressor activity	3.07956158665183	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.96255357208943	bayes_pls_golite062009
transcription activator activity	1.97757778483124	bayes_pls_golite062009
chromatin binding	1.91511881662436	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.35857850481346	bayes_pls_golite062009
sequence-specific DNA binding	1.26862497534835	bayes_pls_golite062009
transcription factor binding	1.23738346570539	bayes_pls_golite062009
transcription corepressor activity	1.16887811832337	bayes_pls_golite062009
structure-specific DNA binding	1.16875264917476	bayes_pls_golite062009
protein binding	0.952480850696098	bayes_pls_golite062009
double-stranded DNA binding	0.885270755906501	bayes_pls_golite062009
transcription cofactor activity	0.627794176881836	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
structure-specific DNA binding	1.32402779550955	bayes_pls_golite062009
double-stranded DNA binding	1.06887513322119	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2