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null null Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. null Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines. null Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: MAP kinase activity
Acc: GO:0004707
Aspect: Molecular Function
Desc: Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Synonyms:
  • p38delta
  • extracellular signal-regulated kinase activity
  • pp44mapk
  • LeMPK3
  • pp42
  • MAPK
  • mitogen activated kinase activity
  • p44mpk
  • MBP kinase I activity
  • MBP kinase II activity
  • Dp38
  • MAP-2 kinase activity
  • mitogen-activated protein kinase activity
  • p42mapk
  • STK26
  • p38-2
  • PMK-2
  • PMK-1
  • myelin basic protein kinase activity
  • p42 mitogen-activated protein kinase activity
  • ATP:protein phosphotransferase (MAPKK-activated) activity
  • ERK
  • PMK-3
Proteins in PDR annotated with:
   This term: 106 [Search]
   Term or descendants: 110 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004707 - MAP kinase activity (interactive image map)

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