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Protein Overview: HFM1

General Information:
Name(s) found: HFM1 / YGL251C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1187 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: synapsis [IGILink to PubMed article][IMPLink to PubMed article]
    DNA unwinding involved in replication [IDALink to PubMed article]
    meiosis [IDALink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTKFDRLGT GKRSRPSPNN IDFNDQSATF KRNKKNSRQP SFKVGLSYNS LLDDCDDENE  60
   61 TEEIFEGRGL QFFDKDDNFS ITADDTQVTS KLFDHDLEQT PDEEAKKPKK VTIRKSAKKC 120
  121 LSTTILPDSF RGVFKFTEFN KMQSEAFPSI YESNENCIIS SPTGSGKTVL FELAILRLIK 180
  181 ETNSDTNNTK IIYIAPTKSL CYEMYKNWFP SFVNLSVGML TSDTSFLETE KAKKCNIIIT 240
  241 TPEKWDLLTR RWSDYSRLFE LVKLVLVDEI HTIKEKRGAS LEVILTRMNT MCQNIRFVAL 300
  301 SATVPNIEDL ALWLKTNNEL PANILSFDES YRQVQLTKFV YGYSFNCKND FQKDAIYNSK 360
  361 LIEIIEKHAD NRPVLIFCPT RASTISTAKF LLNNHIFSKS KKRCNHNPSD KILNECMQQG 420
  421 IAFHHAGISL EDRTAVEKEF LAGSINILCS TSTLAVGVNL PAYLVIIKGT KSWNSSEIQE 480
  481 YSDLDVLQMI GRAGRPQFET HGCAVIMTDS KMKQTYENLI HGTDVLESSL HLNLIEHLAA 540
  541 ETSLETVYSI ETAVNWLRNT FFYVRFGKNP AAYQEVNRYV SFHSVEDSQI NQFCQYLLDT 600
  601 LVKVKIIDIS NGEYKSTAYG NAMTRHYISF ESMKQFINAK KFLSLQGILN LLATSEEFSV 660
  661 MRVRHNEKKL FKEINLSPLL KYPFLTEKKQ SQIIDRVSQK VSLLIQYELG GLEFPSYEGA 720
  721 SKLHQTLVQD KFLVFRHCFR LLKCMVDTFI EKSDGTSLKN TLFLLRSLNG HCWENTPMVL 780
  781 RQLKTIGLVS VRRLIRHGIT NLEEMGHLSD TQIEYYLNLK IGNGIKIKND ISLLPCLNIR 840
  841 TKLENCKIEN EELWLTFKVE ISATFKSSIW HGQHLSLDIE TEKSSGELID FRRLQVNKLQ 900
  901 SPRGFRISAK ISPKLEKIEF SIHCQEIAGL GKTIVYSTDH LASQFSAKTP NIRKDLNSLE 960
  961 KCLFYESSSD GEVGKTSRVS HKDGLEESLS SDDSILDYLN ERKKSSKAVE SAAVIHPEAH1020
 1021 SSSHFSNGRQ VRSNGNYECF HSCKDKTQCR HLCCKEGIPV KYIKEKGPSS IKPVSKPDQI1080
 1081 RQPLLAKNIN TTPHLEKRLN SKPKQWQEEN TDIATVHTLP SKIYNLSQQM SSMEAGEQVL1140
 1141 KSGPENCPEI IPIDLESSDS YSSNTAASSI SDPNGDLDFL GSDIEFE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HFM1 LYS4 NEW1 RBG1 SGD1 SOK1 SSZ1 TCB1 TGL5 TMA46 YEF3 YLR072W ZUO1
    View Details Gavin AC, et al. (2002) ADH1 ENO2 FAR11 FAR3 FBA1 GPM1 HFM1 HSC82 PDC1 ROM2 SNT2 SSE2 TPI1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] PSI-BLAST 37.0 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    2 View Details [108..884] PSI-BLAST 6.522879 Helicase-like "domain" of reverse gyrase; Topoisomerase "domain" of reverse gyrase
    3 View Details [885..971] MSA 3.065994 View MSA. No confident structure predictions are available.
    4 View Details [972..1187] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.4974940028864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.49611313354225 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.38363601832205 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.3625050107782 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.27925703205288 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.249173645231486 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0781650226500197 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.95561462330096E-4 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.5075656948209 bayes_pls_golite062009
  • protein binding
    		•  1.71025015568774 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.71818218589805 bayes_pls_golite062009
  • actin binding
    		•  0.68323011536902 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle