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Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+. Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: methylenetetrahydrofolate dehydrogenase (NADP+) activity
Acc: GO:0004488
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+.
Synonyms:
  • 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity
  • 5,10-methylenetetrahydrofolate:NADP oxidoreductase activity
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle