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Protein Overview: MLH3

General Information:
Name(s) found: MLH3 / YPL164C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 715 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: reciprocal meiotic recombination [TASLink to PubMed article]
    mismatch repair [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQHIRKLDS DVSERLKSQA CTVSLASAVR EIVQNSVDAH ATTIDVMIDL PNLSFAVYDD  60
   61 GIGLTRSDLN ILATQNYTSK IRKMNDLVTM KTYGYRGDAL YSISNVSNLF VCSKKKDYNS 120
  121 AWMRKFPSKS VMLSENTILP IDPFWKICPW SRTKSGTVVI VEDMLYNLPV RRRILKEEPP 180
  181 FKTFNTIKAD MLQILVMHPM ISLNVQYTDK LRINTEVLFR SKNITEGLTK HQQMSQVLRN 240
  241 VFGAIIPPDM LKKVSLKFNE YQIEGIISKM PVGLKDLQFI YINGRRYADS AFQGYVDSLF 300
  301 QAQDFGEKGM SLLKTKSVGK PYRSHPVFIL DVRCPQTIDD LLQDPAKKIV KPSHIRTIEP 360
  361 LIVKTIRSFL TFQGYLTPDK SDSSFEIVNC SQKTATLPDS RIQISKRNQV LNSKMKIARI 420
  421 NSYIGKPAVN GCRINNSTIN YEKIKNIRID GQKSRLRNKL SSRPYDSGFT EDYDSIGKTI 480
  481 TDFSISRSVL AKYEVINQVD KKFILIRCLD QSIHNCPLLV LVDQHACDER IRLEELFYSL 540
  541 LTEVVTGTFV ARDLKDCCIE VDRTEADLFK HYQSEFKKWG IGYETIEGTM ETSLLEIKTL 600
  601 PEMLTSKYNG DKDYLKMVLL QHAHDLKDFK KLPMDLSHFE NYTSVDKLYW WKYSSCVPTV 660
  661 FHEILNSKAC RSAVMFGDEL TRQECIILIS KLSRCHNPFE CAHGRPSMVP IAELK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ILV2 MLH3 MLP2 QCR2 TEP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 100.0 DNA mismatch repair protein MutL
    2 View Details [377..492] deduced N/A No confident structure predictions are available.
    3 View Details [493..654] PSI-BLAST 19.221849 Crystal structure of the MutL C-terminal domain
    4 View Details [655..715] FFAS03 2.02 Crystal structure of the MutL C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle