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View Structure Prediction Details

Protein: MLH3
Organism: Saccharomyces cerevisiae
Length: 715 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLH3.

Description E-value Query
Range
Subject
Range
MUTL_PSEE4 - DNA mismatch repair protein MutL OS=Pseudomonas entomophila (strain L48) GN=mutL PE=3 SV=1
gi|95112861 - gi|95112861|emb|CAK17589.1| DNA mismatch repair protein MutL [Pseudomonas entomophila L48]
575.0 [0..3] [714..5]

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Predicted Domain #1
Region A:
Residues: [1-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQHIRKLDS DVSERLKSQA CTVSLASAVR EIVQNSVDAH ATTIDVMIDL PNLSFAVYDD  60
   61 GIGLTRSDLN ILATQNYTSK IRKMNDLVTM KTYGYRGDAL YSISNVSNLF VCSKKKDYNS 120
  121 AWMRKFPSKS VMLSENTILP IDPFWKICPW SRTKSGTVVI VEDMLYNLPV RRRILKEEPP 180
  181 FKTFNTIKAD MLQILVMHPM ISLNVQYTDK LRINTEVLFR SKNITEGLTK HQQMSQVLRN 240
  241 VFGAIIPPDM LKKVSLKFNE YQIEGIISKM PVGLKDLQFI YINGRRYADS AFQGYVDSLF 300
  301 QAQDFGEKGM SLLKTKSVGK PYRSHPVFIL DVRCPQTIDD LLQDPAKKIV KPSHIRTIEP 360
  361 LIVKTIRSFL TFQGYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.0
Match: 1bknA
Description: DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [377-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPDKSDSSFE IVNCSQKTAT LPDSRIQISK RNQVLNSKMK IARINSYIGK PAVNGCRINN  60
   61 STINYEKIKN IRIDGQKSRL RNKLSSRPYD SGFTEDYDSI GKTITDFSIS RSVLAK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [493-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEVINQVDKK FILIRCLDQS IHNCPLLVLV DQHACDERIR LEELFYSLLT EVVTGTFVAR  60
   61 DLKDCCIEVD RTEADLFKHY QSEFKKWGIG YETIEGTMET SLLEIKTLPE MLTSKYNGDK 120
  121 DYLKMVLLQH AHDLKDFKKL PMDLSHFENY TSVDKLYWWK YS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1x9zA
Description: Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [655-715]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCVPTVFHEI LNSKACRSAV MFGDELTRQE CIILISKLSR CHNPFECAHG RPSMVPIAEL  60
   61 K

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.02
Match: 1x9zA
Description: Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle