YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CSE4

General Information:
Name(s) found: CSE4 / YKL049C [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 229 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome, centromeric region [IGILink to PubMed article]
    extrachromosomal circular DNA [IDALink to PubMed article]
    nuclear nucleosome [IDALink to PubMed article]
    kinetochore [IGILink to PubMed article]
    Biological Process: mitotic sister chromatid segregation [IMPLink to PubMed article]
    2-micrometer plasmid partitioning [IMPLink to PubMed article]
    Molecular Function: sequence-specific DNA binding [IDALink to PubMed article]
    centromeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKQQWVSS AIQSDSSGRS LSNVNRLAGD QQSINDRALS LLQRTRATKN LFPRREERRR  60
   61 YESSKSDLDI ETDYEDQAGN LEIETENEEE AEMETEVPAP VRTHSYALDR YVRQKRREKQ 120
  121 RKQSLKRVEK KYTPSELALY EIRKYQRSTD LLISKIPFAR LVKEVTDEFT TKDQDLRWQS 180
  181 MAIMALQEAS EAYLVGLLEH TNLLALHAKR ITIMKKDMQL ARRIRGQFI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CBF1 CSE4 MIF2
    View Details Qiu et al. (2008) CSE4 HSK3 MIF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MAS2 No Comments Wong J, et all (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CSE4 Huh WK, et al. (2003)
    View Data CSE4 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..229] PSI-BLAST 51.522879 Histone H3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.12722734218139 bayes_pls_golite062009
  • centromeric DNA binding
    		•  2.60445660474495 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.32945404683014 bayes_pls_golite062009
  • DNA binding
    		•  1.81202026929492 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.77431079461635 bayes_pls_golite062009
  • protein binding
    		•  1.2861218811362 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.21195713556272 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07001118921201 bayes_pls_golite062009
  • transcription factor binding
    		•  0.98480383054053 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.86435821849168 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle