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Protein Overview: CBF1

General Information:
Name(s) found: CBF1 / YJR060W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 351 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    kinetochore [TASLink to PubMed article]
    Biological Process: methionine biosynthetic process [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    chromatin assembly or disassembly [IDALink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    centromeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLANNNKL STEDEEIHSA RKRGYNEEQN YSEARKKQRD QGLLSQESND GNIDSALLSE  60
   61 GATLKGTQSQ YESGLTSNKD EKGSDDEDAS VAEAAVAATV NYTDLIQGQE DSSDAHTSNQ 120
  121 TNANGEHKDS LNGERAITPS NEGVKPNTSL EGMTSSPMES TQQSKNDMLI PLAEHDRGPE 180
  181 HQQDDEDNDD ADIDLKKDIS MQPGRRGRKP TTLATTDEWK KQRKDSHKEV ERRRRENINT 240
  241 AINVLSDLLP VRESSKAAIL ACAAEYIQKL KETDEANIEK WTLQKLLSEQ NASQLASANE 300
  301 KLQEELGNAY KEIEYMKRVL RKEGIEYEDM HTHKKQENER KSTRSDNPHE A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CBF1 CSE4 MET28 MET4 MIF2
    View Details Krogan NJ, et al. (2006) CBF1 FYV4 MAM33 MRP1 MRP10 MRP17 MRP21 MRP4 MRP51 MRPL8 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS9 NAM9 NCL1 PET123 RIB4 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 SVL3 SWS2 YDR124W YJR096W YKL151C YSP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YDR132C CBF1 2 Unpublished Fields Lab Data
    View Screen BUR2 CBF1 2 Unpublished Fields Lab Data
    View Screen ROM2 CBF1 2 Unpublished Fields Lab Data
    View Screen RAD53 CBF1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CBF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] deduced N/A No confident structure predictions are available.
    2 View Details [169..351] PSI-BLAST 11.522879 Max protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.58879320178546 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.58751248599889 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.03674713048499 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • promoter binding
    		•  0.94414084000081 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle