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Protein Overview: NCL1

General Information:
Name(s) found: NCL1 / YBL024W [SGD]
Description(s) found:
Found 28 descriptions.
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  • S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 684 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA methylation [IDALink to PubMed article]
    Molecular Function: tRNA (cytosine-5-)-methyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRKNFKKG NKKTFGARDD SRAQKNWSEL VKENEKWEKY YKTLALFPED QWEEFKKTCQ  60
   61 APLPLTFRIT GSRKHAGEVL NLFKERHLPN LTNVEFEGEK IKAPVELPWY PDHLAWQLDV 120
  121 PKTVIRKNEQ FAKTQRFLVV ENAVGNISRQ EAVSMIPPIV LEVKPHHTVL DMCAAPGSKT 180
  181 AQLIEALHKD TDEPSGFVVA NDADARRSHM LVHQLKRLNS ANLMVVNHDA QFFPRIRLHG 240
  241 NSNNKNDVLK FDRILCDVPC SGDGTMRKNV NVWKDWNTQA GLGLHAVQLN ILNRGLHLLK 300
  301 NNGRLVYSTC SLNPIENEAV VAEALRKWGD KIRLVNCDDK LPGLIRSKGV SKWPVYDRNL 360
  361 TEKTKGDEGT LDSFFSPSEE EASKFNLQNC MRVYPHQQNT GGFFITVFEK VEDSTEAATE 420
  421 KLSSETPALE SEGPQTKKIK VEEVQKKERL PRDANEEPFV FVDPQHEALK VCWDFYGIDN 480
  481 IFDRNTCLVR NATGEPTRVV YTVCPALKDV IQANDDRLKI IYSGVKLFVS QRSDIECSWR 540
  541 IQSESLPIMK HHMKSNRIVE ANLEMLKHLL IESFPNFDDI RSKNIDNDFV EKMTKLSSGC 600
  601 AFIDVSRNDP AKENLFLPVW KGNKCINLMV CKEDTHELLY RIFGIDANAK ATPSAEEKEK 660
  661 EKETTESPAE TTTGTSTEAP SAAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CBF1 FYV4 MAM33 MRP1 MRP10 MRP17 MRP21 MRP4 MRP51 MRPL8 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS9 NAM9 NCL1 PET123 RIB4 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 SVL3 SWS2 YDR124W YJR096W YKL151C YSP1
    View Details Gavin AC, et al. (2002) MIS1 MRPL10 NCL1 RPP2B
    View Details Qiu et al. (2008) GCD10 GCD14 NCL1 TRM1 TRM10 TRM8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SGS1 NCL1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NCL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..146] PSI-BLAST 5.69897 Fibrillarin homologue
    3 View Details [147..364] PSI-BLAST 164.10721 No description for 1j4fA_ was found.
    4 View Details [365..494] MSA 1.17399 View MSA. No confident structure predictions are available.
    5 View Details [495..684] MSA 1.01197 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.43145108778901 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.29640050660273 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  0.720972789045101 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.533090627724779 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.455449410561251 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  0.364369105571521 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.0858581024725429 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle