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Protein Overview: TRM1

General Information:
Name(s) found: TRM1 / YDR120C [SGD]
Description(s) found:
Found 29 descriptions.
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  • tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 570 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    nuclear inner membrane [TASLink to PubMed article]
    mitochondrion [TASLink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA methylation [IMPLink to PubMed article]
    Molecular Function: tRNA (guanine-N2-)-methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGFFRIPLK RANLHGMLKA AISKIKANFT AYGAPRINIE DFNIVKEGKA EILFPKKETV  60
   61 FYNPIQQFNR DLSVTCIKAW DNLYGEECGQ KRNNKKSKKK RCAETNDDSS KRQKMGNGSP 120
  121 KEAVGNSNRN EPYINILEAL SATGLRAIRY AHEIPHVREV IANDLLPEAV ESIKRNVEYN 180
  181 SVENIVKPNL DDANVLMYRN KATNNKFHVI DLDPYGTVTP FVDAAIQSIE EGGLMLVTCT 240
  241 DLSVLAGNGY PEKCFALYGG ANMVSHESTH ESALRLVLNL LKQTAAKYKK TVEPLLSLSI 300
  301 DFYVRVFVKV KTSPIEVKNV MSSTMTTYHC SRCGSYHNQP LGRISQREGR NNKTFTKYSV 360
  361 AQGPPVDTKC KFCEGTYHLA GPMYAGPLHN KEFIEEVLRI NKEEHRDQDD TYGTRKRIEG 420
  421 MLSLAKNELS DSPFYFSPNH IASVIKLQVP PLKKVVAGLG SLGFECSLTH AQPSSLKTNA 480
  481 PWDAIWYVMQ KCDDEKKDLS KMNPNTTGYK ILSAMPGWLS GTVKSEYDSK LSFAPNEQSG 540
  541 NIEKLRKLKI VRYQENPTKN WGPKARPNTS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DBP8 DOT1 IMH1 TRM1
    View Details Qiu et al. (2008) GCD10 GCD14 NCL1 SEN15 SEN34 SEN54 TRM1 TRM10 TRM112

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRM1 and NIC96 Huh WK, et al. (2003)
    View Data TRM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..264] PSI-BLAST 17.154902 Protein-L-isoaspartyl O-methyltransferase
    2 View Details [265..570] MSA 2.116946 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.92746815303714 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.99461585647365 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  2.44201549586712 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  2.41876112831625 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.39581687084457 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.29640050660273 bayes_pls_golite062009
  • transferase activity
    		•  2.22303238506686 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.04296107639729 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.66871163498737 bayes_pls_golite062009
  • tRNA (guanine-N2-)-methyltransferase activity
    		•  1.5444293148467 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.1103522853299 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.89325812193225 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.533090627724779 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.455449410561251 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle