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Protein Overview: GCD14

General Information:
Name(s) found: GCD14 / YJL125C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 383 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA methylation [IDALink to PubMed article]
    Molecular Function: tRNA (adenine-N1-)-methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNCFSGYK DLIKEGDLTL IWVSRDNIKP VRMHSEEVFN TRYGSFPHKD IIGKPYGSQI  60
   61 AIRTKGSNKF AFVHVLQPTP ELWTLSLPHR TQIVYTPDSS YIMQRLNCSP HSRVIEAGTG 120
  121 SGSFSHAFAR SVGHLFSFEF HHIRYEQALE EFKEHGLIDD NVTITHRDVC QGGFLIKKGD 180
  181 TTSYEFGNNE TAASLNANVV FLDLPAPWDA IPHLDSVISV DEKVGLCCFS PCIEQVDKTL 240
  241 DVLEKYGWTD VEMVEIQGRQ YESRRQMVRS LNDALERLRD IKRHKLQGVE RRKRMFNNTI 300
  301 DSNDEKVGKR NEDGVPLTEK AKFNPFGKGS RIKEGDSNYK WKEVTKMEAE IKSHTSYLTF 360
  361 AFKVVNRSRD DEKVNEILRS TEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GCD10 GCD14
    View Details Krogan NJ, et al. (2006) GCD10 GCD14
    View Details Qiu et al. (2008) GCD10 GCD14 NCL1 TRM1 TRM10 TRM112 TRM8 TRM82

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GCD14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 137.457575 Probable methyltransferase Rv2118c
    2 View Details [79..312] PSI-BLAST 137.457575 Probable methyltransferase Rv2118c
    3 View Details [313..383] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle