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View Structure Prediction Details

Protein: TRM1
Organism: Saccharomyces cerevisiae
Length: 570 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM1.

Description E-value Query
Range		 Subject
Range
TRM1 - tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localiz...
TRM1_YEAST - tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC ...
 0.0 [1..570] [1..570]
TRM1_SCHPO - tRNA (guanine(26)-N(2))-dimethyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
trm1 - N2,N2-dimethylguanosine tRNA methyltransferase
 0.0 [11..567] [3..536]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [11..567] [3..536]
gi|19347969 - gi|19347969|gb|AAL86317.1| putative N2,N2-dimethylguanine tRNA methyltransferase [Arabidopsis thalia...
 0.0 [34..567] [77..606]
TRMT1 - TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)
 0.0 [32..568] [44..566]

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Predicted Domain #1
Region A:
Residues: [1-264] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGFFRIPLK RANLHGMLKA AISKIKANFT AYGAPRINIE DFNIVKEGKA EILFPKKETV  60
   61 FYNPIQQFNR DLSVTCIKAW DNLYGEECGQ KRNNKKSKKK RCAETNDDSS KRQKMGNGSP 120
  121 KEAVGNSNRN EPYINILEAL SATGLRAIRY AHEIPHVREV IANDLLPEAV ESIKRNVEYN 180
  181 SVENIVKPNL DDANVLMYRN KATNNKFHVI DLDPYGTVTP FVDAAIQSIE EGGLMLVTCT 240
  241 DLSVLAGNGY PEKCFALYGG ANMV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.154902
Match: 1jg1A_
Description: Protein-L-isoaspartyl O-methyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [265-570] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHESTHESAL RLVLNLLKQT AAKYKKTVEP LLSLSIDFYV RVFVKVKTSP IEVKNVMSST  60
   61 MTTYHCSRCG SYHNQPLGRI SQREGRNNKT FTKYSVAQGP PVDTKCKFCE GTYHLAGPMY 120
  121 AGPLHNKEFI EEVLRINKEE HRDQDDTYGT RKRIEGMLSL AKNELSDSPF YFSPNHIASV 180
  181 IKLQVPPLKK VVAGLGSLGF ECSLTHAQPS SLKTNAPWDA IWYVMQKCDD EKKDLSKMNP 240
  241 NTTGYKILSA MPGWLSGTVK SEYDSKLSFA PNEQSGNIEK LRKLKIVRYQ ENPTKNWGPK 300
  301 ARPNTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 2.44201549586712 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
DNA-methyltransferase activity 2.39581687084457 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (guanine-N2-)-methyltransferase activity 1.5444293148467 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle