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Protein Overview: RIB4

General Information:
Name(s) found: RIB4 / YOL143C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 169 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: riboflavin biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: 6,7-dimethyl-8-ribityllumazine synthase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVKGLGKPD QVYDGSKIRV GIIHARWNRV IIDALVKGAI ERMASLGVEE NNIIIETVPG  60
   61 SYELPWGTKR FVDRQAKLGK PLDVVIPIGV LIKGSTMHFE YISDSTTHAL MNLQEKVDMP 120
  121 VIFGLLTCMT EEQALARAGI DEAHSMHNHG EDWGAAAVEM AVKFGKNAF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CBF1 FYV4 MAM33 MRP1 MRP10 MRP17 MRP21 MRP4 MRP51 MRPL8 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS9 NAM9 NCL1 PET123 RIB4 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 SVL3 SWS2 YDR124W YJR096W YKL151C YSP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RIB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] PSI-BLAST 986.39794 Lumazine synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 6,7-dimethyl-8-ribityllumazine synthase activity
    		•  5.61825642183907 bayes_pls_golite062009
  • intramolecular transferase activity, transferring acyl groups
    		•  4.02275160603209 bayes_pls_golite062009
  • catalytic activity
    		•  1.78070169551865 bayes_pls_golite062009
  • riboflavin synthase activity
    		•  1.72639804812167 bayes_pls_golite062009
  • isomerase activity
    		•  0.268840799327499 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle