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View Structure Prediction Details

Protein: CBF1
Organism: Saccharomyces cerevisiae
Length: 351 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBF1.

Description E-value Query
Range
Subject
Range
CBF1_YEAST - Centromere-binding protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CBF1 PE=1 S...
CBF1 - Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including ME...
8.0E-58 [1..351] [1..351]
USF2_MOUSE - Upstream stimulatory factor 2 OS=Mus musculus GN=Usf2 PE=1 SV=1
USF2_RAT - Upstream stimulatory factor 2 OS=Rattus norvegicus GN=Usf2 PE=1 SV=2
6.0E-42 [17..334] [19..346]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-41 [17..334] [19..346]
USF2 - upstream transcription factor 2, c-fos interacting
2.0E-41 [17..334] [19..346]
IPI:IPI00990983.... - Uncharacterized protein OS=Mus musculus GN=Usf2, Tax_Id=10090 Gene_Symbol=Usf2 Uncharacterized prote...
gi|11994804 - gi|11994804|dbj|BAB19965.1| USF2 splicing variant-1 [Rattus norvegicus]
5.0E-38 [17..334] [19..319]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLANNNKL STEDEEIHSA RKRGYNEEQN YSEARKKQRD QGLLSQESND GNIDSALLSE  60
   61 GATLKGTQSQ YESGLTSNKD EKGSDDEDAS VAEAAVAATV NYTDLIQGQE DSSDAHTSNQ 120
  121 TNANGEHKDS LNGERAITPS NEGVKPNTSL EGMTSSPMES TQQSKNDM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [169-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIPLAEHDRG PEHQQDDEDN DDADIDLKKD ISMQPGRRGR KPTTLATTDE WKKQRKDSHK  60
   61 EVERRRRENI NTAINVLSDL LPVRESSKAA ILACAAEYIQ KLKETDEANI EKWTLQKLLS 120
  121 EQNASQLASA NEKLQEELGN AYKEIEYMKR VLRKEGIEYE DMHTHKKQEN ERKSTRSDNP 180
  181 HEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1hloA_
Description: Max protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.58879320178546 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.94414084000081 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle