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Protein Overview: BUB3

General Information:
Name(s) found: BUB3 / YOR026W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome kinetochore [IPILink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQIVQIEQAP KDYISDIKII PSKSLLLITS WDGSLTVYKF DIQAKNVDLL QSLRYKHPLL  60
   61 CCNFIDNTDL QIYVGTVQGE ILKVDLIGSP SFQALTNNEA NLGICRICKY GDDKLIAASW 120
  121 DGLIEVIDPR NYGDGVIAVK NLNSNNTKVK NKIFTMDTNS SRLIVGMNNS QVQWFRLPLC 180
  181 EDDNGTIEES GLKYQIRDVA LLPKEQEGYA CSSIDGRVAV EFFDDQGDDY NSSKRFAFRC 240
  241 HRLNLKDTNL AYPVNSIEFS PRHKFLYTAG SDGIISCWNL QTRKKIKNFA KFNEDSVVKI 300
  301 ACSDNILCLA TSDDTFKTNA AIDQTIELNA SSIYIIFDYE N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) BUB3 GSY2 Q0092
    View Details Qiu et al. (2008) BUB1 BUB3 HSK3 SGO1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUB3 BUB1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BUB3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 72.154902 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dynein binding
    		•  3.17817581100892 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.10036013463576 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.6725482369574 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63776917287392 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.59258100795958 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56901113625383 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.48624129577934 bayes_pls_golite062009
  • actin binding
    		•  1.40831746593132 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • DNA binding
    		•  1.0776875611211 bayes_pls_golite062009
  • tubulin binding
    		•  1.07196649995443 bayes_pls_golite062009
  • microtubule binding
    		•  1.04245147316521 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.963909191437161 bayes_pls_golite062009
  • transcription factor activity
    		•  0.541665384827041 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.535041400676017 bayes_pls_golite062009
  • transporter activity
    		•  0.284701931503833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription factor binding
    		•  0.244641056034795 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
    		• 0.0248988265652406 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0160791658499004 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle