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Protein Overview: ZIP1

General Information:
Name(s) found: ZIP1 / YDR285W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 875 amino acids

    Gene Ontology:
    Cellular Component: transverse filament [IDALink to PubMed article]
    Biological Process: synapsis [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: SUMO polymer binding [IPILink to PubMed article]
    chromatin binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNFFRDSSM GFKPRPNIFA KLRVRDVDSD SSANTVVENS SNCLDVGSSI EGDDTFKKPH  60
   61 KTSTEQELIT SMSLSQRNHG YSDDMEIGSP KKTTSTDQYN RILKNDVAAI ENDTDEDFEI 120
  121 TEVREVSEGV AKETKESHGD PNDSETTLKD SKMHEYTMTN GKAPLHTSIN NSSTSSNDVL 180
  181 LEAFTNTQRI CSNLKQELQK QQQDNAKLKV RLQSYASNSD KINEKVGKYK SCLETLQERI 240
  241 ATLTSHKNNQ ETKLKDLRQN HQLYQRRISG FKTSIENLNK TINDLGKNKK EADAELMKKG 300
  301 KEIEYLKREL DDCSGQLSEE KIKNSSLIQE MGKNREEMIK SIENFFSEDK AHHLLQFNKF 360
  361 EERVHDLFEK KLQKHFDVAK DTLNVGLRNT TVELSSNTET MLKQQYEDIK ENLEQKMSSS 420
  421 KDEMAKTINE LSVTQKGLIM GVQEELLTSS GNIQTALVSE MNNTRQELLD DASQTAKNYA 480
  481 SLENLVKAYK AEIVQSNEYE ERIKHLESER STLSSQKNQI ISSLGTKEAQ YEDLVKKLEA 540
  541 KNIEISQISG KEQSLTEKNE NLSNELKKVQ DQLEKLNNLN ITTKSNYENK ISSQNEIVKA 600
  601 LVSENDTLKQ RIQQLVEIKE NEQKDHTTKL EAFQKNNEQL QKLNVEVVQL KAHELELEEQ 660
  661 NRHLKNCLEK KETGVEESLS DVKTLKQQVI VLKSEKQDIT AEKLELQDNL ESLEEVTKNL 720
  721 QQKVQSQKRE LEQKIKELEE IKNHKRNEPS KKGTQNFTKP SDSPKKNATT SNLFPNNSAA 780
  781 IHSPMKKCPK VDHISKSRIN SSKETSKFND EFDLSSSSND DLELTNPSPI QIKPVRGKIK 840
  841 KGSNCMKPPI SSRKKLLLVE DEDQSLKISK KRRRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) HOP1 RED1 TOP2 ZIP1 ZIP2
    View Details Qiu et al. (2008) HOP1 HSK3 RED1 ZIP1 ZIP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..321] PSI-BLAST 54.9897 Heavy meromyosin subfragment
    2 View Details [322..394] PSI-BLAST 9.69897 Tropomyosin
    3 View Details [395..451] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [452..522] PSI-BLAST 12.0 Tropomyosin
    5 View Details [523..601] PSI-BLAST 12.0 Tropomyosin
    6 View Details [602..663] PSI-BLAST 12.0 Tropomyosin
    7 View Details [664..767] PSI-BLAST 12.0 Tropomyosin
    8 View Details [768..875] MSA 1.763994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.87991790206998 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.27581597876942 bayes_pls_golite062009
  • DNA binding
    		•  2.18852662086781 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.16596178759795 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.16095038479122 bayes_pls_golite062009
  • chromatin binding
    		•  1.68308196781423 bayes_pls_golite062009
  • transcription factor activity
    		•  1.62455239044226 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23930219500076 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.13545283098583 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.09150919349912 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.69917765277148 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.526073636025138 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.284650049512347 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.236060274498333 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0799149587483721 bayes_pls_golite062009
  • histone binding
    		•  0.0391625783266718 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle