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View Structure Prediction Details

Protein: ZIP1
Organism: Saccharomyces cerevisiae
Length: 875 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZIP1.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [57..873] [837..1664]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [24..874] [18..879]
MYSS_CYPCA - Myosin heavy chain, fast skeletal muscle OS=Cyprinus carpio PE=2 SV=2
 0.0 [1..873] [774..1663]
gi|179508, gi|10... - sp|P12883|MYH7_HUMAN Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta), gi|4557773|ref|NP...
 0.0 [24..874] [802..1663]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 0.0 [58..873] [841..1667]

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Predicted Domain #1
Region A:
Residues: [1-321] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNFFRDSSM GFKPRPNIFA KLRVRDVDSD SSANTVVENS SNCLDVGSSI EGDDTFKKPH  60
   61 KTSTEQELIT SMSLSQRNHG YSDDMEIGSP KKTTSTDQYN RILKNDVAAI ENDTDEDFEI 120
  121 TEVREVSEGV AKETKESHGD PNDSETTLKD SKMHEYTMTN GKAPLHTSIN NSSTSSNDVL 180
  181 LEAFTNTQRI CSNLKQELQK QQQDNAKLKV RLQSYASNSD KINEKVGKYK SCLETLQERI 240
  241 ATLTSHKNNQ ETKLKDLRQN HQLYQRRISG FKTSIENLNK TINDLGKNKK EADAELMKKG 300
  301 KEIEYLKREL DDCSGQLSEE K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.9897
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [322-394] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKNSSLIQEM GKNREEMIKS IENFFSEDKA HHLLQFNKFE ERVHDLFEKK LQKHFDVAKD  60
   61 TLNVGLRNTT VEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [395-451] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSNTETMLKQ QYEDIKENLE QKMSSSKDEM AKTINELSVT QKGLIMGVQE ELLTSSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.665 0.939 chromatin binding a.4.1 Homeodomain-like

Predicted Domain #4
Region A:
Residues: [452-522] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQTALVSEM NNTRQELLDD ASQTAKNYAS LENLVKAYKA EIVQSNEYEE RIKHLESERS  60
   61 TLSSQKNQII S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87991790206998 bayes_pls_golite062009
transcription regulator activity 2.27581597876942 bayes_pls_golite062009
DNA binding 2.18852662086781 bayes_pls_golite062009
sequence-specific DNA binding 2.16596178759795 bayes_pls_golite062009
nucleic acid binding 2.16095038479122 bayes_pls_golite062009
chromatin binding 1.68308196781423 bayes_pls_golite062009
transcription factor activity 1.62455239044226 bayes_pls_golite062009
transcription factor binding 1.23930219500076 bayes_pls_golite062009
centromeric DNA binding 1.13545283098583 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09150919349912 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
transcription cofactor activity 0.69917765277148 bayes_pls_golite062009
DNA-dependent ATPase activity 0.526073636025138 bayes_pls_golite062009
telomeric DNA binding 0.284650049512347 bayes_pls_golite062009
cytoskeletal protein binding 0.236060274498333 bayes_pls_golite062009
transcription repressor activity 0.0799149587483721 bayes_pls_golite062009
histone binding 0.0391625783266718 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [523-601] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLGTKEAQYE DLVKKLEAKN IEISQISGKE QSLTEKNENL SNELKKVQDQ LEKLNNLNIT  60
   61 TKSNYENKIS SQNEIVKAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [602-663] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSENDTLKQR IQQLVEIKEN EQKDHTTKLE AFQKNNEQLQ KLNVEVVQLK AHELELEEQN  60
   61 RH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [664-767] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNCLEKKET GVEESLSDVK TLKQQVIVLK SEKQDITAEK LELQDNLESL EEVTKNLQQK  60
   61 VQSQKRELEQ KIKELEEIKN HKRNEPSKKG TQNFTKPSDS PKKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [768-875] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATTSNLFPNN SAAIHSPMKK CPKVDHISKS RINSSKETSK FNDEFDLSSS SNDDLELTNP  60
   61 SPIQIKPVRG KIKKGSNCMK PPISSRKKLL LVEDEDQSLK ISKKRRRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle