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Protein Overview: HOP1

General Information:
Name(s) found: HOP1 / YIL072W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 605 amino acids

    Gene Ontology:
    Cellular Component: lateral element [IPILink to PubMed article]
    condensed nuclear chromosome [IDALink to PubMed article]
    Biological Process: synaptonemal complex assembly [IMPLink to PubMed article]
    synapsis [IMPLink to PubMed article]
    Molecular Function: four-way junction DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKQLVKPK TETKTEITTE QSQKLLQTML TMSFGCLAFL RGLFPDDIFV DQRFVPEKVE  60
   61 KNYNKQNTSQ NNSIKIKTLI RGKSAQADLL LDWLEKGVFK SIRLKCLKAL SLGIFLEDPT 120
  121 DLLENYIFSF DYDEENNVNI NVNLSGNKKG SKNADPENET ISLLDSRRMV QQLMRRFIII 180
  181 TQSLEPLPQK KFLTMRLMFN DNVDEDYQPE LFKDATFDKR ATLKVPTNLD NDAIDVGTLN 240
  241 TKHHKVALSV LSAATSSMEK AGNTNFIRVD PFDLILQQQE ENKLEESVPT KPQNFVTSQT 300
  301 TNVLGNLLNS SQASIQPTQF VSNNPVTGIC SCECGLEVPK AATVLKTCKS CRKTLHGICY 360
  361 GNFLHSSIEK CFTCIFGPSL DTKWSKFQDL MMIRKVFRFL VRKKKGFPAS ITELIDSFIN 420
  421 VEDQNNEVKE RVAFALFVFF LDETLCLDNG GKPSQTIRYV TSSVLVDVKG IVIPNTRKQL 480
  481 NVNHEYKWHF TTSSPKAESF YQEVLPNSRK QVESWLQDIT NLRKVYSEAL SPSSTLQELD 540
  541 LNSSLPTQDP IISGQKRRRY DLDEYLEEDK SSVVNDTIKA KDFDESVPAK IRKISVSKKT 600
  601 LKSNW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) HOP1 RED1 TOP2 ZIP1 ZIP2
    View Details Qiu et al. (2008) DMC1 HOP1 HOP2 MND1 NDJ1 RED1 SPO13 TOP2 ZIP1 ZIP2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 44.0 The spindle assembly checkpoint protein mad2
    2 View Details [298..362] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [363..605] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.13055115474904 bayes_pls_golite062009
  • protein binding
    		•  0.818584450437447 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.84147289283175 bayes_pls_golite062009
  • histone binding
    		•  2.18177552065219 bayes_pls_golite062009
  • protein binding
    		•  1.32925779020231 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0641566670887 bayes_pls_golite062009
  • DNA binding
    		•  0.971448192185972 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.967231932888801 bayes_pls_golite062009
  • chromatin binding
    		•  0.880691867408093 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.853862782088463 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.831882636066806 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.831882636066806 bayes_pls_golite062009
  • methylated histone residue binding
    		•  0.635303636820801 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.592444465044507 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.326699327690106 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.290550172892431 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.290236218269237 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0935432513162235 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle