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Protein Overview: OSH7

General Information:
Name(s) found: OSH7 / YHR001W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: sterol transport [IGILink to PubMed article]
    late endosome to vacuole transport [IMPLink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    sterol metabolic process [IGILink to PubMed article]
    Molecular Function: oxysterol binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALNKLKNIP SLTNSSHSSI NGIASNAANS KPSGADTDDI DENDESGQSI LLNIISQLKP  60
   61 GCDLSRITLP TFILEKKSML ERITNQLQFP DVLLEAHSNK DGLQRFVKVV AWYLAGWHIG 120
  121 PRAVKKPLNP ILGEHFTAYW DLPNKQQAFY IAEQTSHHPP ESAYFYMIPE SNIRVDGVVV 180
  181 PKSKFLGNSS AAMMEGLTVL QFLDIKDANG KPEKYTLSQP NVYARGILFG KMRIELGDHM 240
  241 VIMGPKYQVD IEFKTKGFIS GTYDAIEGTI KDYDGKEYYQ ISGKWNDIMY IKDLREKSSK 300
  301 KTVLFDTHQH FPLAPKVRPL EEQGEYESRR LWKKVTDALA VRDHEVATEE KFQIENRQRE 360
  361 LAKKRAEDGV EFHSKLFRRA EPGEDLDYYI YKHIPEGTDK HEEQIRSILE TAPILPGQTF 420
  421 TEKFSIPAYK KHGIQKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OSH7 RPN10 RPN11 RPN12 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT2 RPT3 RPT4 RPT6 UBP6
    View Details Ho Y, et al. (2002) CAF4 CCT2 CCT3 CCT5 CCT6 ENT2 OSH7 SRP54 TCP1 YBL029W
    View Details Qiu et al. (2008) OSH6 OSH7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OSH7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..437] Pfam 242.886057 Oxysterol-binding protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxysterol binding
    		•  5.22335714957681 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • phosphoinositide binding
    		•  2.2725849852584 bayes_pls_golite062009
  • phospholipid binding
    		•  2.08170907241909 bayes_pls_golite062009
  • binding
    		•  1.90982981425351 bayes_pls_golite062009
  • cholesterol binding
    		•  1.74311885098566 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.72950454023501 bayes_pls_golite062009
  • lipid binding
    		•  1.52883493550389 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle