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Protein Overview: OSH6

General Information:
Name(s) found: OSH6 / YKR003W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 448 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    peripheral to membrane of membrane fraction [IDALink to PubMed article]
    Biological Process: sterol transport [IGILink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    sterol metabolic process [IGILink to PubMed article]
    Molecular Function: oxysterol binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKKLTVGS DSHRLSKSSF SSNKSSHSAT KDQPIDTDDI DEDDESGHNI ILNIISQLRP  60
   61 GCDLTRITLP TFILEKKSML ERVTNQLQFP EFLLQAHSEK DPLKRFLYVM KWYLAGWHIA 120
  121 PKAVKKPLNP VLGEYFTAYW DLPNKQQAYY ISEQTSHHPP ECAYFYMIPE SSIRVDGVVI 180
  181 PKSRFLGNSS AAMMDGSTVL QFLDIKDGNG KPEKYVLTQP NVYVRGILFG KMRIELGDHM 240
  241 IIKSPNFQAD IEFKTKGYVF GTYDAIEGTV KDYDGNAYYE ISGKWNDVMY LKDLKQPRSS 300
  301 PKVFLDTHKE SPLRPKVRPL SEQGEYESRK LWKKVTDALA VRNHPVATEE KFQIEDHQRQ 360
  361 LAKKRIEDGV EFHPKLFRRS KPGEDLDYCI YKNIPVDEDP EKQIRSILQI APILPGQQFT 420
  421 DKFFIPAFEK IKSQKKMIEN EKQNPAKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ART5 JID1 LYS12 OSH6 YHR138C
    View Details Qiu et al. (2008) OSH6 OSH7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OSH6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..448] Pfam 240.853872 Oxysterol-binding protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxysterol binding
    		•  5.03243665769579 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • phosphoinositide binding
    		•  2.2725849852584 bayes_pls_golite062009
  • phospholipid binding
    		•  2.08170907241909 bayes_pls_golite062009
  • binding
    		•  1.90982981425351 bayes_pls_golite062009
  • cholesterol binding
    		•  1.74311885098566 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.72950454023501 bayes_pls_golite062009
  • lipid binding
    		•  1.52883493550389 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle