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Protein Overview: MGS1

General Information:
Name(s) found: MGS1 / YNL218W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 587 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: DNA replication [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of DNA replication [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKRTSVEQ LISCPICSRK VFFSLINSHL DICGKEKSKP SSRPQTVSSL LAGPKKRKQA  60
   61 NSEKFIDLEN KDHEIKPGLK SESDDIEIVE NESKRFKAAP STDFAKSIVE PASSRDQLHN 120
  121 DYESRWLQKI SHLPLSEKLR PKELRDYVGQ QHILSQDNGT LFKYIKQGTI PSMILWGPPG 180
  181 VGKTSLARLL TKTATTSSNE SNVGSRYFMI ETSATKANTQ ELRGIFEKSK KEYQLTKRRT 240
  241 VLFIDEIHRF NKVQQDLLLP HVENGDIILI GATTENPSFQ LNNALISRCL IFVLEKLNVN 300
  301 ELCIVLSRGI ALLNKCRKQV WNIENPLKLS RSILEYVVDL SVGDTRRALN MLEMIEVSTR 360
  361 ERKADEEELS IDDVRDIIKN NSSNGLNTYY DPKGDNHYDT ISAFHKSIRG GDENASLYYL 420
  421 ARMLQGGEDP LYVARRMIRI ASEDIGLRDS SLLPLAVAAH DAVMKVGLPE ADLALAQCCV 480
  481 ALARAPKSVE LYRAWKKLRA MMSENMYSLA SSEIPMHIRN APTKLMEELG YHKGYKYNPD 540
  541 YIEGKVQQDY FPKEVLEKCP NKTDLKFLDG KHLGDKEDPD LRQSYQG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) ACT1 MGS1
    View Details Gavin AC, et al. (2002) MGS1 PCM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNF1 MGS1 2 Uetz P, et al. (2000)
    View Screen TEM1 MGS1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MGS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] deduced N/A No confident structure predictions are available.
    2 View Details [111..138]
    [298..368]    		 PSI-BLAST 169.70927 Replication factor C
    3 View Details [139..297]
    [369..508]    		 PSI-BLAST 169.70927 Replication factor C
    4 View Details [509..587] MSA 1.050994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.49611313354225 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.428373955572763 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.424644011903671 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.424583288440993 bayes_pls_golite062009
  • nucleotide binding
    		•  0.422354428195324 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.3625050107782 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.27925703205288 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ATP binding
    		•  0.04834397972685 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0149501427627318 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.00365326483311895 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.95561462330096E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle