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Protein Overview: NDT80

General Information:
Name(s) found: NDT80 / YHR124W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 627 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [IDALink to PubMed article]
    Biological Process: transcription [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    meiosis [IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEMENTDPV LQDDLVSKYE RELSTEQEED TPVILTQLNE DGTTSNYFDK RKLKIAPRST  60
   61 LQFKVGPPFE LVRDYCPVVE SHTGRTLDLR IIPRIDRGFD HIDEEWVGYK RNYFTLVSTF 120
  121 ETANCDLDTF LKSSFDLLVE DSSVESRLRV QYFAIKIKAK NDDDDTEINL VQHTAKRDKG 180
  181 PQFCPSVCPL VPSPLPKHQI IREASNVRNI TKMKKYDSTF YLHRDHVNYE EYGVDSLLFS 240
  241 YPEDSIQKVA RYERVQFASS ISVKKPSQQN KHFSLHVILG AVVDPDTFHG ENPGIPYDEL 300
  301 ALKNGSKGMF VYLQEMKTPP LIIRGRSPSN YASSQRITVR TPSSVNSSQN STKRKMPSMA 360
  361 QPLNESCLNA RPSKRRSKVA LGAPNSGASI SPIKSRQSTP MEASKENEDP FFRPNKRVET 420
  421 LEHIQNKLGA LKNQCPDSSL KYPSSSSRGM EGCLEKEDLV YSSSFSVNMK QIELKPARSF 480
  481 EHENIFKVGS LAFKKINELP HENYDITIEK KSMEQNYLRP EIGSRSECKT SYGNELSLSN 540
  541 ISFSILPNSA ENFHLETALF PATEEDVPRT FSRILETGSF QNYYQKMDAE NADRVYSKGV 600
  601 KLIASGTLPS GIFNREELFE EDSFYKY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..434] MSA 1.003997 View MSA. No confident structure predictions are available.
    2 View Details [435..627] deduced N/A No confident structure predictions are available.
    3 View Details [524..627] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.42929256050781 bayes_pls_golite062009
  • DNA binding
    		•  5.06641178315703 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.74995074999042 bayes_pls_golite062009
  • binding
    		•  4.35229901672243 bayes_pls_golite062009
  • transcription factor activity
    		•  4.30059567378483 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72947352424854 bayes_pls_golite062009
  • transcription activator activity
    		•  2.56828839945617 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.23604897773023 bayes_pls_golite062009
  • protein binding
    		•  1.90381218061757 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.27337392672914 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.18312413193055 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.15539761996001 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.952279913363481 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.75467711075231 bayes_pls_golite062009
  • transcription factor binding
    		•  0.628837188707778 bayes_pls_golite062009
  • chromatin binding
    		•  0.4119609397091 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle