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Protein Overview: FBP1

General Information:
Name(s) found: FBP1 / YLR377C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 348 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: gluconeogenesis [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: fructose 1,6-bisphosphate 1-phosphatase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTLVNGPRR DSTEGFDTDI ITLPRFIIEH QKQFKNATGD FTLVLNALQF AFKFVSHTIR  60
   61 RAELVNLVGL AGASNFTGDQ QKKLDVLGDE IFINAMRASG IIKVLVSEEQ EDLIVFPTNT 120
  121 GSYAVCCDPI DGSSNLDAGV SVGTIASIFR LLPDSSGTIN DVLRCGKEMV AACYAMYGSS 180
  181 THLVLTLGDG VDGFTLDTNL GEFILTHPNL RIPPQKAIYS INEGNTLYWN ETIRTFIEKV 240
  241 KQPQADNNNK PFSARYVGSM VADVHRTFLY GGLFAYPCDK KSPNGKLRLL YEAFPMAFLM 300
  301 EQAGGKAVND RGERILDLVP SHIHDKSSIW LGSSGEIDKF LDHIGKSQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] PSI-BLAST 977.228787 Fructose-1,6-bisphosphatase
    2 View Details [210..348] PSI-BLAST 977.228787 Fructose-1,6-bisphosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fructose 1,6-bisphosphate 1-phosphatase activity
    		•  4.65500634914117 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  3.16528473469754 bayes_pls_golite062009
  • fructose-2,6-bisphosphate 2-phosphatase activity
    		•  2.93988797179951 bayes_pls_golite062009
  • catalytic activity
    		•  2.13229228332707 bayes_pls_golite062009
  • phosphatase activity
    		•  1.80881730120084 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.75330931312215 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.56919997723952 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.22694473598142 bayes_pls_golite062009
  • binding
    		•  0.97662061117191 bayes_pls_golite062009
  • inositol-1(or 4)-monophosphatase activity
    		•  0.0921499329725725 bayes_pls_golite062009
  • hydrolase activity
    		•  0.06056335004637 bayes_pls_golite062009
  • protein binding
    		•  0.0338617836572318 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle