YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: OTU1

General Information:
Name(s) found: OTU1 / YFL044C [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 301 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein deubiquitination [IDALink to PubMed article]
    ubiquitin cycle [IGILink to PubMed article][IPILink to PubMed article]
    regulation of transcription [IMPLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLKVTGAGI NQVVTLKQDA TLNDLIEHIN VDVKTMRFGY PPQRINLQGE DASLGQTQLD  60
   61 ELGINSGEKI TIESSDSNES FSLPPPQPKP KRVLKSTEMS IGGSGENVLS VHPVLDDNSC 120
  121 LFHAIAYGIF KQDSVRDLRE MVSKEVLNNP VKFNDAILDK PNKDYAQWIL KMESWGGAIE 180
  181 IGIISDALAV AIYVVDIDAV KIEKFNEDKF DNYILILFNG IHYDSLTMNE FKTVFNKNQP 240
  241 ESDDVLTAAL QLASNLKQTG YSFNTHKAQI KCNTCQMTFV GEREVARHAE STGHVDFGQN 300
  301 R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OTU1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] deduced N/A No confident structure predictions are available.
    2 View Details [95..232] Pfam 38.79588 OTU-like cysteine protease No confident structure predictions are available.
    3 View Details [233..301] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.96735553959103 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.13534310479552 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • DNA binding
    		•  1.95013248594294 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.74961503597682 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20242512567523 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.874003454509364 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.47951889934838 bayes_pls_golite062009
  • DNA binding
    		•  4.31051339571017 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.04689255235626 bayes_pls_golite062009
  • transcription factor activity
    		•  3.28758716579796 bayes_pls_golite062009
  • binding
    		•  2.99742524370422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.05542379535543 bayes_pls_golite062009
  • transcription activator activity
    		•  1.97757778483124 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.44763794968807 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.26862497534835 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23738346570539 bayes_pls_golite062009
  • chromatin binding
    		•  1.10179307236186 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.776754909146767 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.627794176881836 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle