YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: FOB1

General Information:
Name(s) found: FOB1 / YDR110W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 566 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: chromatin silencing at rDNA [IDALink to PubMed article]
    extrachromosomal circular DNA accumulation involved in cell aging [IMPLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    negative regulation of DNA replication [IDALink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    Molecular Function: rDNA binding [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKPRYNDVL FDDDDSVPSE SVTRKSQRRK ATSPGESRES SKDRLLILPS MGESYTEYVD  60
   61 SYLNLELLER GERETPIFLE SLTRQLTQKI YELIKTKSLT ADTLQQISDK YDGVVAENKL 120
  121 LFLQRQYYVD DEGNVRDGRN NDKIYCEPKH VYDMVMATHL MNKHLRGKTL HSFLFSHFAN 180
  181 ISHAIIDWVQ QFCSKCNKKG KIKPLKEYKR PDMYDKLLPM ERIHIEVFEP FNGEAIEGKY 240
  241 SYVLLCRDYR SSFMWLLPLK STKFKHLIPV VSSLFLTFAR VPIFVTSSTL DKDDLYDICE 300
  301 EIASKYGLRI GLGLKSSARF HTGGILCIQY ALNSYKKECL ADWGKCLRYG PYRFNRRRNK 360
  361 RTKRKPVQVL LSEVPGHNAK FETKRERVIE NTYSRNMFKM AGGKGLIYLE DVNTFALANE 420
  421 ADNSCNNNGI LHNNNIGNDN FEEEVQKQFD LTEKNYIDEY DDLAHDSSEG EFEPNTLTPE 480
  481 EKPPHNVDED RIESTGVAAP MQGTEEPEKG DQKESDGASQ VDQSVEITRP ETSYYQTLES 540
  541 PSTKRQKLDQ QGNGDQTRDF GTSMEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FOB1 NET1 NSR1 TOP1 UTP9

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO21 FOB1 2 Unpublished Fields Lab Data
    View Screen FRT2 FOB1 2 Unpublished Fields Lab Data
    View Screen YOR203W FOB1 2 Unpublished Fields Lab Data
    View Screen PRP42 FOB1 2 Unpublished Fields Lab Data
    View Screen RRP17 FOB1 2 Unpublished Fields Lab Data
    View Screen NOG1 FOB1 2 Unpublished Fields Lab Data
    View Screen SPT2 FOB1 2 Uetz P, et al. (2000)
    View Screen RAD53 FOB1 2 Unpublished Fields Lab Data
    View Screen YJL147C FOB1 2 Unpublished Fields Lab Data
    View Screen NTR2 FOB1 2 Unpublished Fields Lab Data
    View Screen SST2 FOB1 2 Unpublished Fields Lab Data
    View Screen TEM1 FOB1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FOB1 Huh WK, et al. (2003)
    View Data FOB1 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..566] deduced N/A No confident structure predictions are available.
    2 View Details [131..484] FFAS03 5.37 N-terminal Zn binding domain of HIV integrase; Retroviral integrase, catalytic domain
    3 View Details [485..566] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • exonuclease activity
    		•  2.69169803889636 bayes_pls_golite062009
  • nuclease activity
    		•  2.63308556411438 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.43802973446357 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.22832306273638 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.21640837000075 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.15202443486046 bayes_pls_golite062009
  • DNA binding
    		•  1.88388568255929 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.66403897673963 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.57871253412659 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.54823157746404 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.44766638837068 bayes_pls_golite062009
  • binding
    		•  1.42021256417703 bayes_pls_golite062009
  • transcription factor activity
    		•  1.18792852183348 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.16950079926796 bayes_pls_golite062009
  • catalytic activity
    		•  1.16880796007849 bayes_pls_golite062009
  • hydrolase activity
    		•  1.02227964399726 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.01792206204118 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.985835839433199 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.91438167081716 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.819269466567015 bayes_pls_golite062009
  • endonuclease activity
    		•  0.591008475846166 bayes_pls_golite062009
    		• 0.300511724300705 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.244405458380391 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.152950127352174 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0924765766526223 bayes_pls_golite062009
  • protein binding
    		•  0.0799098348667361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.056513663571923 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle