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Progression of the cell from its inception to the end of its lifespan. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication. The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: extrachromosomal circular DNA accumulation involved in cell aging
Acc: GO:0007580
Aspect: Biological Process
Desc: Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication.
Synonyms:
  • extrachromosomal circular DNA accumulation during cell ageing
  • extrachromosomal circular DNA accumulation during cell aging
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007580 - extrachromosomal circular DNA accumulation involved in cell aging (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle