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View Structure Prediction Details

Protein: CLU1
Organism: Saccharomyces cerevisiae
Length: 1277 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLU1.

Description E-value Query
Range
Subject
Range
CLU1 - eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in...
CLU_YEAST - Clustered mitochondria protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLU1 PE...
0.0 [1..1258] [1..1258]
CG8443-PA - This gene is referred to in FlyBase by the symbol Dmel\CG8443 (CG8443, FBgn0034087). It is a protein...
0.0 [2..1272] [94..1383]
KIAA0664 - KIAA0664
gi|162318882, gi... - gi|162318882|gb|AAI56941.1| KIAA0664 [synthetic construct], gi|162317964|gb|AAI56058.1| KIAA0664 [sy...
0.0 [158..1272] [1..1082]
clu-1 - status:Confirmed UniProt:P34466 protein_id:CAA81605.1
0.0 [2..1208] [5..1175]
gi|5103827, gi|2... - gi|5103827|gb|AAD39657.1|AC007591_22 ESTs gb|F20110 and gb|F20109 come from this gene. [Arabidopsis ...
0.0 [9..1272] [28..1114]
IF3X_DICDI - Putative eukaryotic translation initiation factor 3 subunit - Dictyostelium discoideum (Slime mold)
0.0 [3..1140] [15..1198]

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Predicted Domain #1
Region A:
Residues: [1-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKKEEVKN ATVKVTVKLP KEDNHSHNTK HLKKTQSSKN NDISFEIGKE SKIQTVLDVL  60
   61 AMIPSSKYLT NVGLKTIEGD SQLSDEMSIK EIVGEKSELK LQLILKPYSA REALKHVITV 120
  121 RDFIGFAQET SDGLSEFAIS TGSSFSSLPL GPIKERSKQE EKDEKSDPEE KKNTFKDVTD 180
  181 EEKLKFNEMV HEVFSSFKNS SINKLLTSES NIITPCVRSL SFAPYNPVPP FYRSKGHLFY 240
  241 LQIVTLEGES FYITAIPSGF YVNKSNSTKF DPSPKENTDE NAHSSLIYYS LFDLIASRSK 300
  301 KFISHVQAFE KKLSALDSTS YVRPSNTFLH KPWFVSSLPP NNPDYLRLQT AALDTTPERN 360
  361 FNDEFQAIKD LTTSTLQDRI EMERLFSKVV HEFSVTAASG AMSIFYSDFV AMNPESPTRD 420
  421 QIFLKDNIFY SYVSDVSGNY EGKGGDEAAI AASNQDLKTI NILNRLHMHE VRYLLTTVVE 480
  481 FAGRRILAQT PVPGLLATMG NKIVKDANTG EEVTEDFVND INVKYGLDEG LGKIVYDADF 540
  541 DSVLEKKFVK AFHLKKHKVN GTELAFSSQS KGIVGFDKRR YILDLANTYP LDINFARQNF 600
  601 DNIEETGNRY PHRQTLLRPE LVEKWWNNKV EKEGVEFEKA YEENLFSYNP DAYQVEGIED 660
  661 ANVDEMSNYL QKEVIPSVIQ DYLSGNLSTP YNGEHLADTL HKNGINMRYL GKIIEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [717-802]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQKELDSQIV HYEQNLKAVE QDNKEYEDWE KSYLQKIENM IKERQAKINK LVQEGKEVPK  60
   61 ELTEDLKLND EEIKKPTDGK PVVVAY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.58148987937399 bayes_pls_golite062009
protein binding 0.856276659140234 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [803-991]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELVPLIKIS ELEIVSRSLK HVLKDLSKDV PVFLVPSLVA YVFNMLVGIN YNADPKPEPV  60
   61 DEFYPVNKCS FAKLTRSELL EAVSKQAFLR FRHQLPSNWI EAYMENPFTL IRSVSYKFGI 120
  121 QLLNKEYFFT REQLESYKQS LDKKIRNKFV EPPTTFSLSD LTIIPRVKFS EYTSSVSEEF 180
  181 WAQGASMIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [992-1076]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDKQSALTLL AQSITVLEDV NNILHPAVAE KYLSLSAIYN KLALYPEAIA FCRKACTIYE  60
   61 RVSGIDSFEM MRALTNLAIL EFSNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1077-1154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYNATVVYN RLAEILKVYE LPKIHHPAPT SIFNHLEQLA LGVQDTKLAI EVLGQLSSYV  60
   61 VELEGKDSLA YGYTESRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.07985546140154 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
transcription regulator activity 0.921062221092247 bayes_pls_golite062009
nucleic acid binding 0.75712113503301 bayes_pls_golite062009
DNA binding 0.665813461397509 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1155-1277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNLFAALKDF HRALEHITVT QGIFTKQLGM NHTHSAQSRQ WVNGLSSLIM DLKQKKQLAQ  60
   61 DQMSTTGSNS AGHKKTNHRQ KKDDVKPELA NKSVDELLTF IEGDSSNSKS KNKTNNKKKH 120
  121 GKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle