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Protein Overview: CG8443-PA

General Information:
Name(s) found: CG8443-PA / FBpp0086380 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8443 (CG8443, FBgn0034087). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12074090..12081754. It has the cytological map location 52F5-52F7. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 18 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1448 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 3 complex [ISS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALETEAKNS NATATGDATA TATKASGKAK ENNNTAGGKK NLNPNSNQQN SNQNLVNGNG  60
   61 TAADGPAAKK KGKKNRNKSP TEPTTEAVLS NGHAEKPTVV DAVEDNADTN ANVEKPQEGG 120
  121 APDAEADGDD IDLDALQDIG ITVNISSPGA DLLCVQLSSM ELVQEIHQLL MDREETCHRT 180
  181 CFSLQLDNVT LDNFAELKSI NNLEQGSTIK VVEEPYTMRE ARIHVRHVRD LLKNLDPADA 240
  241 YNGIDCTSLT YLNTITQGDL LDKKRTRPDS VDCTPPEYVT PGVSDPPILP LHPNVKNAKG 300
  301 PQALKVLTTS AWNPPPGPRK LHGDLMYLYV VTMEDKRFHI SACSKGFFIN QSTDDTFNPK 360
  361 PDNPSHLSHS LIDLLSHISP SFRRAFQTIQ KRRTMRHAFE RVATPYQVYQ WAAPILEHTV 420
  421 DAIRAEDAFS SKLGYEEHIP GQTRDWNEEL QTTRELPRKT LPERLLRERA IFKVHGDFVT 480
  481 AATRGAMAVI DGNVLAINPG EDTKMQMFIW NNIFFSMGFD VRDHYKELGG DAAAFVAPRY 540
  541 DLHGVRVYNA VDIEGLYTLG TVVVDYRGYR VTAQSIIPGI LEREQEQSVV YGSIDFGKTV 600
  601 LSHPKYLELL RQAGKHLKIL PHVVLNERDE PVELCSSVEC KGIIGNDGRH YILDLLRTFP 660
  661 PDVNFLKLQD VQLSKELVDM GFPIEHRHKL CCLRQELLEA FIEDRHVNFI RIAAARLQQL 720
  721 TTIKQSEKSE ANPVPALEGA EAASKVNGAE KPDDKEKKNE EEEKKERSTS GEARAAAIVN 780
  781 AIREAQSNVA TSNEVQAAEV VKRACAAVGS LKEKEFDFRF NPDVFSPGIR HADGEEGTSL 840
  841 AKQKVLVQEA AEFLVLKQIP AFIKEHMSHS SSPIDGQSLT ESLHSHGINV RYLGKVIKIL 900
  901 SQMPRMDYLH RIAVLELIVR ATKHIYYTYM QNTEPLHLSA AISHFLNCLL TNGPVNPAVS 960
  961 SEEAHKKRGN GGKHNKHKSS KGGKGQQQQQ TTGNQNGSSS GSSNSSSASD WTLMTPRSLW1020
 1021 QQIRKEAKVY WDWELDCDSI ETAVSKYGIL RISLMRAFCL KVGIQVLLRE YNFESKHKPT1080
 1081 FGDDDIVNVF PIVKHISPRA TDAYNFYTTG QAKIQQGLFK EGYELISGAL NLLNNVFGAL1140
 1141 HQENGSCLRM LARLSYLLGD AQDALAIQQR AVIMSERVNG MDHPSTILEY THLSLYSFAN1200
 1201 GHVGMSLKLL YRARYLMVLI CGEDHPEVAL IDSNISLILH ALGEYELSLR FIEHALKLNL1260
 1261 KYFGDKDMHV ALSYHLMART QSCMGDFRSA LNNEKETYSF YKSQLGENHE KTRDSAECLR1320
 1321 LLTQQAVLLQ RKMNDIYSSG KLTSDLPPIH ITPPSMGSVL DMLNTINGIL FVKISRKDIV1380
 1381 KVRSEIEKHF KTDSTENEVN DAINSIVAAA NNNGEAEDAV SKDIKEQPEA GKQLTNGDKA1440
 1441 AATEATSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..262] MSA 1.051948 View MSA. No confident structure predictions are available.
    3 View Details [263..402] FFAS03 2.13 NMR Structure of the human C14orf129 gene product, HSPC210. Northeast Structural Genomics target HR969.
    4 View Details [403..645] deduced N/A No confident structure predictions are available.
    5 View Details [646..831] deduced N/A No confident structure predictions are available.
    6 View Details [832..1352] PSI-BLAST 4.221849 No description for 2ooeA was found.
    7 View Details [1353..1448] PSI-BLAST 47.30103 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  0.988649793903839 bayes_pls_golite062009
  • protein binding
    		•  0.879208011887064 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • protein binding
    		•  1.65083457326273 bayes_pls_golite062009
  • binding
    		•  1.48701537593139 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.14122558270332 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle