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View Structure Prediction Details

Protein: CG8443-PA
Organism: Drosophila melanogaster
Length: 1448 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG8443-PA.

Description E-value Query
Range
Subject
Range
gi|74186877 - gi|74186877|dbj|BAE20503.1| unnamed protein product [Mus musculus]
1322.0 [0..63] [1402..44]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALETEAKNS NATATGDATA TATKASGKAK ENNNTAGGKK NLNPNSNQQN SNQNLVNGNG  60
   61 TAADGPAAKK KGKKNRNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [79-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPTEPTTEAV LSNGHAEKPT VVDAVEDNAD TNANVEKPQE GGAPDAEADG DDIDLDALQD  60
   61 IGITVNISSP GADLLCVQLS SMELVQEIHQ LLMDREETCH RTCFSLQLDN VTLDNFAELK 120
  121 SINNLEQGST IKVVEEPYTM REARIHVRHV RDLLKNLDPA DAYNGIDCTS LTYLNTITQG 180
  181 DLLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [263-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRTRPDSVD CTPPEYVTPG VSDPPILPLH PNVKNAKGPQ ALKVLTTSAW NPPPGPRKLH  60
   61 GDLMYLYVVT MEDKRFHISA CSKGFFINQS TDDTFNPKPD NPSHLSHSLI DLLSHISPSF 120
  121 RRAFQTIQKR RTMRHAFERV 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.13
Match: 1sgoA
Description: NMR Structure of the human C14orf129 gene product, HSPC210. Northeast Structural Genomics target HR969.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.988649793903839 bayes_pls_golite062009
protein binding 0.879208011887064 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [403-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATPYQVYQWA APILEHTVDA IRAEDAFSSK LGYEEHIPGQ TRDWNEELQT TRELPRKTLP  60
   61 ERLLRERAIF KVHGDFVTAA TRGAMAVIDG NVLAINPGED TKMQMFIWNN IFFSMGFDVR 120
  121 DHYKELGGDA AAFVAPRYDL HGVRVYNAVD IEGLYTLGTV VVDYRGYRVT AQSIIPGILE 180
  181 REQEQSVVYG SIDFGKTVLS HPKYLELLRQ AGKHLKILPH VVLNERDEPV ELCSSVECKG 240
  241 IIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [646-831]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDGRHYILDL LRTFPPDVNF LKLQDVQLSK ELVDMGFPIE HRHKLCCLRQ ELLEAFIEDR  60
   61 HVNFIRIAAA RLQQLTTIKQ SEKSEANPVP ALEGAEAASK VNGAEKPDDK EKKNEEEEKK 120
  121 ERSTSGEARA AAIVNAIREA QSNVATSNEV QAAEVVKRAC AAVGSLKEKE FDFRFNPDVF 180
  181 SPGIRH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [832-1352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADGEEGTSLA KQKVLVQEAA EFLVLKQIPA FIKEHMSHSS SPIDGQSLTE SLHSHGINVR  60
   61 YLGKVIKILS QMPRMDYLHR IAVLELIVRA TKHIYYTYMQ NTEPLHLSAA ISHFLNCLLT 120
  121 NGPVNPAVSS EEAHKKRGNG GKHNKHKSSK GGKGQQQQQT TGNQNGSSSG SSNSSSASDW 180
  181 TLMTPRSLWQ QIRKEAKVYW DWELDCDSIE TAVSKYGILR ISLMRAFCLK VGIQVLLREY 240
  241 NFESKHKPTF GDDDIVNVFP IVKHISPRAT DAYNFYTTGQ AKIQQGLFKE GYELISGALN 300
  301 LLNNVFGALH QENGSCLRML ARLSYLLGDA QDALAIQQRA VIMSERVNGM DHPSTILEYT 360
  361 HLSLYSFANG HVGMSLKLLY RARYLMVLIC GEDHPEVALI DSNISLILHA LGEYELSLRF 420
  421 IEHALKLNLK YFGDKDMHVA LSYHLMARTQ SCMGDFRSAL NNEKETYSFY KSQLGENHEK 480
  481 TRDSAECLRL LTQQAVLLQR KMNDIYSSGK LTSDLPPIHI T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 2ooeA
Description: No description for 2ooeA was found.

Predicted functions:

Term Confidence Notes
protein binding 1.65083457326273 bayes_pls_golite062009
binding 1.48701537593139 bayes_pls_golite062009
nucleic acid binding 0.14122558270332 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1353-1448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPSMGSVLDM LNTINGILFV KISRKDIVKV RSEIEKHFKT DSTENEVNDA INSIVAAANN  60
   61 NGEAEDAVSK DIKEQPEAGK QLTNGDKAAA TEATSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.30103
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle