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Protein Overview: INM1

General Information:
Name(s) found: INM1 / YHR046C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 295 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: inositol phosphate dephosphorylation [IDALink to PubMed article]
    Molecular Function: inositol-1(or 4)-monophosphatase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIDLASIEK FLCELATEKV GPIIKSKSGT QKDYDLKTGS RSVDIVTAID KQVEKLIWES  60
   61 VKTQYPTFKF IGEESYVKGE TVITDDPTFI IDPIDGTTNF VHDFPFSCTS LGLTVNKEPV 120
  121 VGVIYNPHIN LLVSASKGNG MRVNNKDYDY KSKLESMGSL ILNKSVVALQ PGSAREGKNF 180
  181 QTKMATYEKL LSCDYGFVHG FRNLGSSAMT MAYIAMGYLD SYWDGGCYSW DVCAGWCILK 240
  241 EVGGRVVGAN PGEWSIDVDN RTYLAVRGTI NNESDEQTKY ITDFWNCVDG HLKYD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DPB2 DPB3 DPB4 INM1 MBA1 MCM2 POL2 RPN4
    View Details Ho Y, et al. (2002) CLU1 INM1 MAM33 PGM2 YPR015C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data INM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 464.522879 Inositol monophosphatase
    2 View Details [150..295] PSI-BLAST 464.522879 Inositol monophosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphatase activity
    		•  6.94859134959555 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.73672244222293 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  6.00413152384861 bayes_pls_golite062009
  • hydrolase activity
    		•  4.43275987578288 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  3.57479316466542 bayes_pls_golite062009
  • inositol-1(or 4)-monophosphatase activity
    		•  3.34662957972704 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  2.14796627243145 bayes_pls_golite062009
  • catalytic activity
    		•  2.13229228332707 bayes_pls_golite062009
  • fructose 1,6-bisphosphate 1-phosphatase activity
    		•  1.61382250100271 bayes_pls_golite062009
  • binding
    		•  1.53051725610674 bayes_pls_golite062009
  • protein binding
    		•  0.286223098418614 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle