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Protein Overview: CKA2

General Information:
Name(s) found: CKA2 / YOR061W [SGD]
Description(s) found:
Found 33 descriptions.
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  • Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 339 amino acids

    Gene Ontology:
    Cellular Component: protein kinase CK2 complex [IDALink to PubMed article]
    Biological Process: G2/M transition of mitotic cell cycle [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IMPLink to PubMed article]
    flocculation via cell wall protein-carbohydrate interaction [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    response to DNA damage stimulus [IDALink to PubMed article]
    regulation of transcription from RNA polymerase III promoter [IDALink to PubMed article]
    regulation of transcription from RNA polymerase I promoter [IDALink to PubMed article]
    cellular ion homeostasis [IPILink to PubMed article]
    Molecular Function: protein kinase CK2 activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLPPSTLNQ KSNRVYSVAR VYKNACEERP QEYWDYEQGV TIDWGKISNY EIINKIGRGK  60
   61 YSEVFSGRCI VNNQKCVIKV LKPVKMKKIY RELKILTNLT GGPNVVGLYD IVQDADSKIP 120
  121 ALIFEEIKNV DFRTLYPTFK LPDIQYYFTQ LLIALDYCHS MGIMHRDVKP QNVMIDPTER 180
  181 KLRLIDWGLA EFYHPGVDYN VRVASRYHKG PELLVNLNQY DYSLDLWSVG CMLAAIVFKK 240
  241 EPFFKGSSNP DQLVKIATVL GTKELLGYLG KYGLHLPSEY DNIMRDFTKK SWTHFITSET 300
  301 KLAVPEVVDL IDNLLRYDHQ ERLTAKEAMD HKFFKTKFE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAB3 CDC73 CHD1 CKA1 CKA2 CKB1 CKB2 CTR9 HOT1 LEO1 PAF1 POB3 RRP7 RTF1 SPT16 UTP22 YLR407W
    View Details (MIPS) Mewes HW, et al. (2004) CKA1 CKA2 CKB1 CKB2
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Gavin AC, et al. (2006) CKA1 CKA2 CKB1 CKB2
    View Details Gavin AC, et al. (2002) ABF2 ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CAB3 CBF5 CDC73 CHD1 CKA1 CKA2 CKB1 CKB2 CMS1 CTI6 CTR9 DBP2 DBP8 DEP1 DIA4 DIM1 DIP2 DIS3 DOT6 EAF3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 GCN1 HCA4 HHF1, HHF2 HOT1 HSL1 HTA2 IML1 IMP3 IMP4 IOC3 ISW1 ISW2 KRE33 KRR1 LCP5 LEO1 LTV1 LYS12 MED4 MPP10 MRD1 MRPS28 MVD1 NAN1 NHP10 NIP1 NOB1 NOC2 NOC4 NOP1 NOP14 NOP56 NOP58 NOP6 NRD1 NUP120 NUP145 NUP84 NUP85 PAF1 PHO23 PNO1 POB3 PRE6 PRE9 PRP43 PRT1 PWP2 RCL1 RCO1 RET1 RML2 ROK1 RPD3 RPG1 RPP2B RRP12 RRP7 RRP9 RSC8 RTF1 RTG2 RVB2 RXT2 RXT3 SAM1 SAP30 SCL1 SDS3 SEC13 SEC16 SEC21 SEC23 SEC31 SEH1 SIN3 SLX9 SOF1 SPN1 SPT16 SPT6 SSA4 STM1 STO1 TIF1, TIF2 TIF35 TOP1 TSR1 TUP1 UME1 UME6 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YOR059C YTA7
    View Details Ho Y, et al. (2002) ARP4 ATE1 CDC25 CDC28 CDC33 CEG1 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 DCP2 DIP2 DUN1 EAF1 EDC3 EDE1 ENP1 ENP2 EPL1 ESA1 ESF1 ESF2 ESL2 FKH1 FPR3 FYV8 GCD2 GCD7 GCN3 GDE1 GLC7 HAS1 HHF1, HHF2 HOT1 HRR25 HTB1 IMD2 IMD3 KRE33 KRI1 LAA1 LCP5 LHP1 LIF1 MAM33 MBP1 MDS3 MGM101 MPH1 MRPL1 MSS116 NAN1 NET1 NOC3 NOP1 NOP12 NOP2 NOP56 NOP7 NUG1 PBY1 PDI1 PMA1 PNO1 POB3 POL2 POR1 PRP40 PTC5 PUF6 PWP1 PWP2 RNH203 RPF2 RPM2 RRP1 RRP14 RRP15 RRP5 SAH1 SAP185 SEC2 SEC23 SFB3 SFP1 SGM1 SIN3 SIT4 SPB1 SPT16 SPT2 SRP1 SSF1 SUI2 SUI3 TAF14 TAF4 TFP1 TGL1 TIF4631 TIF6 TIP41 TOP2 TRA1 TRL1 TSR1 TUF1 UBP12 URE2 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 VMR1 VPS73 WTM2 YCR087W YDR102C YGR017W YMR144W YRA1 YTM1
    View Details Qiu et al. (2008) CKA1 CKA2 CKB1 CKB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CKB1 CKA2 2 Unpublished Fields Lab Data
    View Screen RHO3 CKA2 2 Drees BL, et al. (2001)
    View Screen CKB2 CKA2 2 Unpublished Fields Lab Data
    View Screen CKA2 CKA1 2 Unpublished Fields Lab Data
    View Screen CKA2 CKB2 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CKA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..22]
    [195..339]    		 PSI-BLAST 1147.0 Protein kinase CK2, alpha subunit
    2 View Details [23..42]
    [86..108]
    [127..194]    		 PSI-BLAST 1147.0 Protein kinase CK2, alpha subunit
    3 View Details [43..85]
    [109..126]    		 PSI-BLAST 1147.0 Protein kinase CK2, alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholine receptor activator activity
    		•  5.9159846946654 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  5.68265749805481 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • structural molecule activity
    		•  3.82327979736517 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • MAP kinase 2 activity
    		•  3.27009208121248 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.30873410607588 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.30873410607588 bayes_pls_golite062009
  • histone kinase activity (H3-S10 specific)
    		•  2.30449166929476 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  1.74645334586495 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • activin binding
    		•  1.69795678545106 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.66976264488423 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • activin receptor activity
    		•  1.64506335968643 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.45392497707807 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.16995153203536 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.11664317075762 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.03605423743048 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.870666814073948 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.82317428935631 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.728917900114111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.705634826374884 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.705634826374884 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.693246095477001 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • cyclin-dependent protein kinase activating kinase activity
    		•  0.529121666062889 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.435457844706269 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.149958560815481 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.149958560815481 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.14842991990838 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  0.0794053647730006 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle