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Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: insulin receptor substrate binding
Acc: GO:0043560
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
Synonyms:
  • IRS binding
  • IRS [protein] binding
  • insulin receptor substrate [protein] binding
Proteins in PDR annotated with:
   This term: 30 [Search]
   Term or descendants: 30 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043560 - insulin receptor substrate binding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle