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Protein Overview: NRG1

General Information:
Name(s) found: NRG1 / YDR043C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 231 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pseudohyphal growth [IGILink to PubMed article]
    response to pH [IDALink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    glucose metabolic process [IMPLink to PubMed article]
    biofilm formation [IGILink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFYPYNYSNL NVSTMPALPG ISAFDGMQDE ENVEISPERK YQTLLPVLTN SHVVENELKH  60
   61 KLNKTAFDFR YQTKSENGSE KWEPKYLITP NLQTRSVSFD NSSVQYNSDS SEKSSLSQLT 120
  121 CNSSIIQQPE NGIVSNDAYN KMANSRYSLK TRKQRTDPRN TLSDEEDLEQ RRKYICKICA 180
  181 RGFTTSGHLA RHNRIHTGEK NHCCPYKGCT QRFSRHDNCL QHYRTHLKKG Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NRG1 Huh WK, et al. (2003)
    View Data NRG1 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] MSA 147.506997 View MSA. Confident ab initio structure predictions are available.
    2 View Details [128..231] PSI-BLAST 74.218487 No description for 1lu6A_ was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle