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Protein Overview: PGA2

General Information:
Name(s) found: PGA2 / YNL149C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 129 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    Biological Process: secretory pathway [IMPLink to PubMed article]
    mitochondrion organization [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVAETWVD TWMAKLVNYD YKHFIRLVII VGGYLLLRNI ASRELAKKQL AAQVEKDKRD  60
   61 KEEKRSKDLI DKPDDAATAE TTSFGWGKKT RRRVKRQQEL FENALEEAKR RNQGLDPDSD 120
  121 ADIEELLEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH2 PGA2 PSA1 YNR062C
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PGA2 and TRX3 Hazbun TR, et al. (2003)
    View Data PGA2 and SPC42 Hazbun TR, et al. (2003)
    View Data PGA2 and SPC42 Unpublished Data
    View Data PGA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] Pcons 1.55 Multiple antibiotic resistance repressor, MarR

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.92638462203672 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.22253996678636 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14288680048889 bayes_pls_golite062009
  • DNA binding
    		•  2.10600827813244 bayes_pls_golite062009
  • transcription factor activity
    		•  1.32901697252559 bayes_pls_golite062009
  • protein binding
    		•  1.2080702238979 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.436849299068334 bayes_pls_golite062009
  • structural molecule activity
    		•  0.241691756012358 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.215472749582216 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.145583411541476 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0101820413115041 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle